Marine n-3 Fatty Acids and Colorectal Cancer: Is There a Real Link?

To the Editor: Oh et al. (1) investigated the possible inverse association between consumption of fish/n-3 highly unsaturated fatty acids (HUFAs, marine omega-3 fatty acids mainly consisting of icosapentaenoic acid and docosahexaenoic acid) and the risk of colorectal cancer in the Nurses' Health Study, but failed to observe any link. However, we have documented elevated apoptosis in normal colonic membranes in Japanese patients, in the Dietary...