Role of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population

Nanoparticles are considered a primary vehicle for targeted therapies because they can pass biological barriers and enter and distribute within cells by energy-dependent pathways1,2,3. So far, most studies have shown that nanoparticle properties, such as size4,5,6 and surface7,8, can influence how cells internalize nanoparticles. Here, we show that uptake of nanoparticles by cells is also influenced by their cell cycle phase. Although cells in...