Identification of a novel antibody associated with autoimmune pancreatitis

Published on Dec 10, 2009in The New England Journal of Medicine74.699
· DOI :10.1056/NEJMOA0903068
Luca Frulloni44
Estimated H-index: 44
(University of Verona),
Claudio Lunardi35
Estimated H-index: 35
(University of Verona)
+ 7 AuthorsAntonio Puccetti24
Estimated H-index: 24
(Istituto Giannina Gaslini)
BackgroundAutoimmune pancreatitis is characterized by an inflammatory process that leads to organ dysfunction. The cause of the disease is unknown. Its autoimmune origin has been suggested but never proved, and little is known about the pathogenesis of this condition. MethodsTo identify pathogenetically relevant autoantigen targets, we screened a random peptide library with pooled IgG obtained from 20 patients with autoimmune pancreatitis. Peptide-specific antibodies were detected in serum specimens obtained from the patients. ResultsAmong the detected peptides, peptide AIP1-7 was recognized by the serum specimens from 18 of 20 patients with autoimmune pancreatitis and by serum specimens from 4 of 40 patients with pancreatic cancer, but not by serum specimens from healthy controls. The peptide showed homology with an amino acid sequence of plasminogen-binding protein (PBP) of Helicobacter pylori and with ubiquitin-protein ligase E3 component n-recognin 2 (UBR2), an enzyme highly expressed in acinar cells ...
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