In Vivo Stimulation of De Novo Collagen Production Caused by Cross-linked Hyaluronic Acid Dermal Filler Injections in Photodamaged Human Skin

Objective

To determine whether endogenous synthesis of new extracellular matrix may contribute to the degree and duration of clinical benefits derived from cross-linked hyaluronic acid dermal filler injections.

Design

In vivo biochemical analyses after filler injections.

Setting

Academic referral center.

Participants

Eleven healthy volunteers (mean age, 74 years) with photodamaged forearm skin....