Review paper
Autoimmunity as a Double Agent in Tumor Killing and Cancer Promotion
Abstract
Cancer immunotherapy through manipulation of the immune system holds great potential for the treatment of human cancers. However, recent trials targeting the negative immune regulators CTLA4, PD-1 and PD-L1 demonstrated that clinically significant antitumor responses were often associated with the induction of autoimmune toxicity. This finding suggests that the same immune mechanisms that elicit autoimmunity may also contribute to the...
Paper Details
Title
Autoimmunity as a Double Agent in Tumor Killing and Cancer Promotion
Published Date
Mar 18, 2014
Journal
Volume
5
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