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Original paper

Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells

Volume: 90, Issue: 3, Pages: 457 - 463
Published: Jan 31, 2011
Abstract
Tissue-type plasminogen activator (t-PA) is produced by endothelial cells (EC) and is responsible for the removal of intravascular fibrin deposits. We investigated whether expression of t-PA by EC is under epigenetic control.Methylation analysis of the proximal t-PA promoter revealed a stretch of unmethylated CpG dinucleotides from position -121 to +59, while upstream CpG dinucleotides were all methylated. In contrast, in human primary...
Paper Details
Title
Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells
Published Date
Jan 31, 2011
Volume
90
Issue
3
Pages
457 - 463
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