Original paper
Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells
Abstract
Tissue-type plasminogen activator (t-PA) is produced by endothelial cells (EC) and is responsible for the removal of intravascular fibrin deposits. We investigated whether expression of t-PA by EC is under epigenetic control.Methylation analysis of the proximal t-PA promoter revealed a stretch of unmethylated CpG dinucleotides from position -121 to +59, while upstream CpG dinucleotides were all methylated. In contrast, in human primary...
Paper Details
Title
Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells
Published Date
Jan 31, 2011
Journal
Volume
90
Issue
3
Pages
457 - 463