[Offsprings of preconceptionally irradiated parents. Final report of a longitudinal study 1976-1994 and recommendations for patients' advisory].

Published on Jan 1, 2004in Strahlentherapie Und Onkologie3.621
· DOI :10.1007/S00066-004-1223-4
Thomas Herrmann21
Estimated H-index: 21
Grit Thiede1
Estimated H-index: 1
+ 1 AuthorsLutz Voigtmann6
Estimated H-index: 6
BACKGROUND: Many young adults with cancer of good prognosis seek advice from their doctors, because they are concerned about their ability to have children and about potential hereditary diseases in the children conceived or fathered after cancer therapy. PATIENTS AND METHODS: Results of repeated examinations of 61 children over a period of 20 years are reported. One of their parents had received radiotherapy for malignant disease (only three had additional chemotherapy). Radiation doses to the gonads ranged from 0.01 to 2 Gy. The most frequent indications for radiotherapy were Hodgkin's disease (n=25), seminomas (n=7), thyroid cancer (n=3), and malignant melanomas (n=3) RESULTS: There was a trend to premature birth with 52.5% of the babies born before term. Yet, all had normal birth weight and delivery was inconspicuous. The skeletal maturation was retarded, but development was still in the normal range of German children. There were no chromosome aberrations, normal mental and intellectual development, and no malignancy among these children. A trend to an increased frequency of developmental disturbances and four moderately severe malformations were observed; however, no direct association with radiation treatment could be demonstrated. One child had a balanced translocation (5;17) which it inherited from the unirradiated parent. CONCLUSION: During the first consultation of young adult cancer patients, before the start of treatment, the problems of fertility and of therapy-induced mutations and hereditary diseases as well as developmental damage of the offspring need to be addressed directly by the radiation oncologist. Decisions on cryoconservation of sperm, fixation of the ovaries and dosimetry of the gonads during radiotherapy have to be made before the start of treatment. The rate of radiation-induced hereditary diseases and developmental damage in the children conceived or fathered after curative radiotherapy of one parent is estimated to increase by <0.1% (after gonadal exposure of 1 Gy). However, at present, heritable damage potentially induced by chemotherapy cannot be adequately quantified yet.
Cited By9
#2T. Kroner (Winterthur Museum, Garden and Library)
Eine Krebserkrankung und ihre Behandlung konnen sich auf Sexualitat und Fertilitat (Fruchtbarkeit) des Patienten auswirken. Unfruchtbarkeit und Storungen des sexuellen Erlebens bedeuten eine erhebliche Einbuse an Lebensqualitat und konnen Patienten schwer belasten. Besondere Probleme stellen sich beim Auftreten maligner Tumoren wahrend einer Schwangerschaft. Zur Erhaltung der Fertilitat bestehen fur Manner und Frauen verschiedene Moglichkeiten wie Spermakonservierung resp. Kryopraservation von E...
#1S. Tran (AMU: Aix-Marseille University)H-Index: 2
#2Romain Boissier (AMU: Aix-Marseille University)H-Index: 13
Last. Eric Lechevallier (AMU: Aix-Marseille University)H-Index: 29
view all 5 authors...
Objective To compare the options available for prostate cancer management and their consequences on fertility for men, in order to best advise these men to choose their treatment, especially if they are young, with no child with their current partner. Methods A literature review on prostate cancer and fertility over the last 26 years was carried out on PubMed database. The literature was based on evidence and practical considerations. Twenty-nine articles were selected according to their relevan...
#1Nooshin Banaee (IAU: Islamic Azad University)H-Index: 5
#2Hassan Ali Nedaie (Tehran University of Medical Sciences)H-Index: 9
Last. Mohammad Jamali (Tehran University of Medical Sciences)H-Index: 7
view all 5 authors...
Background: In radiaƟ on therapy, peripheral dose or the dose outside the radiotherapy field, is important when anatomic al structures with very low dose tolerances are involved. One of these criƟ cal organs in pelvic irradiaƟ on is tesƟ s. The amount of radiaƟ on delivered to the testes in radiotherapy must be kept as small as possible, consistent with the limit dose of this organ. The threshold doses for temporary and permanent sterility are 0.15 Gy and 6-8 Gy, respecƟ vely. Therefore, in pelv...
#1Mohamed Nazmy (Cairo University)H-Index: 6
#2Maha M. El-TaherH-Index: 2
Last. Mohamed M LotayefH-Index: 4
view all 5 authors...
Objectives: To assess the value of external shielding of the testis during pelvic radiotherapy. Material and Methods: Nineteen patients, receiving radiotherapy to the pelvis with the lower border of the field at the obturator foramen, were randomly selected. A 5 half value layer cerrobent shield was positioned at the inferior border of the field. The dose to the testis was measured with and without the shield. Observations were made regarding the reflex cremaster contraction and phantom measurem...
To measure the scattered dose to ovaries and testes from radiotherapy for common pediatric malignancies and to assess the relevant risks for radiation-induced gonadal damage and hereditary disorders in future generations. Radiotherapy for central nervous system tumors, acute leukemia, neuroblastoma, Hodgkin's disease, Wilms' tumor, and sarcoma was simulated on three humanoid phantoms representing patients of 5, 10, and 15 years of age. Ovarian and testicular dose measurements were performed usin...
Background and Purpose: The German Hodgkin Study Group (GHSG), including more than 500 participating centers, established a central radiotherapy (RT) reference center to improve quality of treatment, starting with the first study generation in 1978. More than 11,000 patients with Hodgkin's lymphoma (HL) have been enrolled into these trials. Extensive continuing quality assurance programs (QAPs) during the study generations have been performed. The purpose of the present article is to summarize t...
#1Andreas SchuckH-Index: 29
#2Victoria HamelmannH-Index: 1
Last. Normann WillichH-Index: 34
view all 12 authors...
Purpose: To analyze the effect of pelvic radiotherapy on ovarian function in prepubertal and pubertal girls and young adult women. Patients and Methods: In a retrospective monoinstitutional analysis, patients 15 Gy to the ovaries developed hormone failure. In one case of a patient receiving an ovarian dose of 15 Gy, hormone failure was not found. In case of pelvic irradiation excluding at least one ovary, approximately half of the patients developed ovarian dysfunction, probably also due to the ...
#1Mei-Jou Chen (NTU: National Taiwan University)H-Index: 25
#2Jehn Hsiahn Yang (NTU: National Taiwan University)H-Index: 26
Last. Yu-Shih Yang (NTU: National Taiwan University)H-Index: 60
view all 5 authors...
Objective To present a case of successful pregnancy after conservative bilateral gonadectomy without adjuvant chemotherapy and radiotherapy in a 46,XY gonadal dysgenetic woman with gonadoblastoma and malignant germ cell tumor. Design Case report. Setting Infertility center in university hospital. Patient(s) An 18-year-old female with 46,XY karyotype underwent bilateral gonadectomy, and the pathology revealed gonadoblastoma with malignant mixed germ cell tumor. Intervention(s) Chromosomal analysi...
#1Dirk Boehmer (Charité)H-Index: 20
#2Harun BadakhshiH-Index: 18
Last. Volker BudachH-Index: 64
view all 5 authors...
Purpose: To determine the dose received by the unshielded testicles during a course of 20-MV conventional external-beam radiotherapy for patients with localized prostate cancer. Critical evaluation of the potential impact on fertility and hormonal impairment in these patients according to the literature. Patients and Methods: The absolute dose received by the testicles of 20 randomly selected patients undergoing radiotherapy of prostate cancer was measured by on-line thermoluminescence dosimetry...
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.