Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2
Abstract
Receptor tyrosine kinase activity is known to occur in the absence of extracellular stimuli. Importantly, this “background” level of receptor phosphorylation is insufficient to effect a downstream response, suggesting that strict controls are present and prohibit full activation. Here a mechanism is described in which control of FGFR2 activation is provided by the adaptor protein Grb2. Dimeric Grb2 binds to the C termini of two FGFR2 molecules....
Paper Details
Title
Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2
Published Date
Jun 1, 2012
Journal
Volume
149
Issue
7
Pages
1514 - 1524
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