Architecture of the mammalian mechanosensitive Piezo1 channel
Abstract
Piezo proteins are evolutionarily conserved and functionally diverse mechanosensitive cation channels. However, the overall structural architecture and gating mechanisms of Piezo channels have remained unknown. Here we determine the cryo-electron microscopy structure of the full-length (2,547 amino acids) mouse Piezo1 (Piezo1) at a resolution of 4.8 A. Piezo1 forms a trimeric propeller-like structure (about 900 kilodalton), with the...
Paper Details
Title
Architecture of the mammalian mechanosensitive Piezo1 channel
Published Date
Sep 21, 2015
Journal
Volume
527
Issue
7576
Pages
64 - 69
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