Matrix metalloproteinase-8 overexpression prevents proper tissue repair

The collagenolytic matrix metalloproteinase-8 (MMP-8) is essential for normal tissue repair but is often overexpressed in wounds with disrupted healing. Our aim was to study the impact of a local excess of this neutrophil-derived proteinase on wound healing using recombinant adenovirus-driven transduction of full-length Mmp8 (AdMMP-8).The effect of MMP-8 overexpression was evaluated in dermal fibroblasts and in two wound healing models in male...