Magnus S. Ågren
University of Copenhagen
Matrix metalloproteinaseInternal medicineEndocrinologySurgeryPathologyMolecular biologyRandomized controlled trialChemistryExtracellular matrixGrowth factorGranulation tissueInflammationOcclusive dressingWound healingPathogenesisAnesthesiaZincMedicineAnastomosisGastroenterologyPharmacology
133Publications
42H-index
4,252Citations
Publications 98
Newest
#1Susanne Clemen Capion (UCPH: University of Copenhagen)
#2Henrietta B L Jørgensen (UCPH: University of Copenhagen)
Last. Arne Borgwardt (UCPH: University of Copenhagen)H-Index: 1
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Rapid wound closure is important after arthroplasty procedures to prevent postoperative complications. Platelets are rich in growth factors and leukocytes contribute to innate immunity. We hypothesized that topical leukocyte platelet-rich plasma (L-PRP) derived from the blood of patients would be beneficial to wound healing. In this randomized controlled trial, patients subjected to elective total hip arthroplasty (THA) were assigned by concealed allocation either L-PRP application onto the sutu...
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#1Magnus S. Ågren (UCPH: University of Copenhagen)H-Index: 42
Last. Lars N. JorgensenH-Index: 52
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#1Ceylan Türlü (UCPH: University of Copenhagen)
#2Nicholas WillumsenH-Index: 17
Last. Magnus S. Ågren (UCPH: University of Copenhagen)H-Index: 42
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Anastomotic leakage (AL) is a devastating complication after colorectal surgery, possibly due to the loss of stabilizing collagen fibers in the submucosa. Our aim was to assess the formation of collagen in the colon versus the rectum with or without transforming growth factor (TGF)-β1 exposure in a human cellular model of colorectal repair. Primary fibroblasts were isolated by an explant procedure from clinically resected tissue rings during anastomosis construction in 19 consecutive colorectal ...
1 CitationsSource
#1Marie Kjaer (UCPH: University of Copenhagen)H-Index: 2
Last. Magnus S. Ågren (UCPH: University of Copenhagen)H-Index: 42
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Background The enteroendocrine hormone glucagon-like peptide- (GLP-) 2 is a potent trophic factor in the gastrointestinal tract. The GLP-2 receptor (GLP-2R) is expressed in the stroma of the large bowel wall, which is the major therapeutic target area to prevent anastomotic leakage. We investigated the efficacy of the long-acting GLP-2 analogue ZP1849 on colonic anastomotic wound healing. Methods Eighty-seven male Wistar rats were stratified into four groups and received daily treatment with veh...
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#1Klaus Kirketerp-Møller (UCPH: University of Copenhagen)H-Index: 13
#2Thomas BjarnsholtH-Index: 69
Last. Magnus S. ÅgrenH-Index: 42
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#1Magnus S. Ågren (UCPH: University of Copenhagen)H-Index: 42
#2Khaled GhathianH-Index: 2
Last. Lars N. JorgensenH-Index: 52
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: Malodour from the axilla is commonly caused by specific microbes, and may be inhibited by zinc oxide. The aim of this study was to determine the effects of zinc oxide on the axillary microbiota, odour and pH in a randomized, double-blind, placebo-controlled trial in 30 healthy volunteers. In each participant one axilla was treated with zinc oxide and the other with a placebo for 13 days. The microbiota and pH were analysed before and during treatment. At the final visit, the participants judge...
1 CitationsSource
#1Ursula Mirastschijski (University of Bremen)H-Index: 20
#2Blaž Lupše (University of Bremen)H-Index: 1
Last. Magnus S. ÅgrenH-Index: 42
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Inflammatory processes in the skin augment collagen degradation due to the up-regulation of matrix metalloproteinases (MMPs). The aim of the present project was to study the specific impact of MMP-3 on collagen loss in skin and its interplay with the collagenase MMP-13 under inflammatory conditions mimicked by the addition of the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α). Skin explants from MMP-3 knock-out (KO) mice or from transgenic (TG) mice overexpressing MMP-3 in the skin an...
9 CitationsSource
#1Lea Lorentzen (UCPH: University of Copenhagen)H-Index: 3
#2N. A. Henriksen (UCPH: University of Copenhagen)H-Index: 15
Last. Lars N. Jorgensen (UCPH: University of Copenhagen)H-Index: 52
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Background and Aims:Hernia formation is associated with alterations of collagen metabolism. Collagen synthesis and degradation cause a systemic release of products, which are measurable in serum. Recently, we reported changes in type V and IV collagen metabolisms in patients with inguinal and incisional hernia. The aim of this study was to determine if the altered collagen metabolism was persistent after hernia repair.Material and Methods:Patients who had undergone repairs for inguinal hernia (n...
3 CitationsSource
#1Louise BundgaardH-Index: 2
#2Magnus S. Ågren (UCPH: University of Copenhagen)H-Index: 42
Last. Ulrich auf dem KellerH-Index: 35
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#1Patricia L Danielsen (UWA: University of Western Australia)H-Index: 7
#2Wang Ru (Boston Children's Hospital)H-Index: 1
Last. Ying Cen (Sichuan University)H-Index: 1
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Reason for withdrawal from publication This protocol has been withdrawn as authors were unable to progress the review.
1 CitationsSource