Heparin-modified graphene oxide loading anti-cancer drug and growth factor with heat stability, long-term release property and lower cytotoxicity

Published on Oct 1, 2015in RSC Advances3.119
· DOI :10.1039/C5RA14203B
Ting Wu5
Estimated H-index: 5
,
Ting Wu11
Estimated H-index: 11
+ 8 AuthorsXiang Cai10
Estimated H-index: 10
Sources
Abstract
To realize the long-term release property of drugs, reduce the cytotoxicity of anti-cancer drugs and improve the heat stability of the growth factor, a heparin-modified graphene oxide (Hep-GO) was prepared through a click reaction between azide-modified graphene oxide and propargylamine-modified heparin. Then, the Hep-GO was used as a carrier of doxorubicin hydrochloride (DOX) and granulocyte colony stimulating factor (G-CSF), and a Hep-GO/DOX/G-CSF complex was fabricated. UV-Vis analysis was carried out to study the colloidal stability of Hep-GO in aqueous solution. A thermogravimetric test was used to determine its composition. Then, the loading process, in vitro release behavior, heat stability and cytotoxicity of the Hep-GO/DOX/G-CSF complex were studied. The results showed that the Hep-GO/DOX/G-CSF complex displayed heat stability, long-term drug release property and lower drug cytotoxicity, suggesting the great potential application of Hep-GO as a multifunctional drug delivery system.
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