To realize the long-term release property of drugs, reduce the cytotoxicity of anti-cancer drugs and improve the heat stability of the growth factor, a heparin-modified graphene oxide (Hep-GO) was prepared through a click reaction between azide-modified graphene oxide and propargylamine-modified heparin. Then, the Hep-GO was used as a carrier of doxorubicin hydrochloride (DOX) and granulocyte colony stimulating factor (G-CSF), and a Hep-GO/DOX/G-CSF complex was fabricated. UV-Vis analysis was carried out to study the colloidal stability of Hep-GO in aqueous solution. A thermogravimetric test was used to determine its composition. Then, the loading process, in vitro release behavior, heat stability and cytotoxicity of the Hep-GO/DOX/G-CSF complex were studied. The results showed that the Hep-GO/DOX/G-CSF complex displayed heat stability, long-term drug release property and lower drug cytotoxicity, suggesting the great potential application of Hep-GO as a multifunctional drug delivery system.
The co-delivery of drug and gene has become the primary strategy in cancer and other disease therapy. To co-deliver hydrophobic drug and functional gene efficiently into tumor cells, a star-shaped copolymer (PP-PLLD-Arg) with a photochemical internalization effect consisting of a porphyrin (PP) core and arginine-functionalized poly(l-lysine) dendron (PLLD-Arg) arms has been designed, and used to co-deliver docetaxel (DOC) and MMP-9 shRNA plasmid for nasopharyngeal cancer therapy. It was found th...
Abstract A new cyclodextrin derivative (CD-PLLD) consisting of a β-cyclodextrin core and poly( l -lysine) dendron arms was prepared by the click conjugation of per-6-azido-b-cyclodextrin with propargyl focal point poly( l -lysine) dendron of third generation, and then used for docetaxel (DOC) and the best siRNA plasmid targeting MMP-9 (pMR3) co-delivery. Different from commonly used amphiphilic copolymers with cationic character, the as obtained cyclodextrin derivative may be used directly for t...
A novel star-shaped polymer, porphyrin-poly(L-lysine) dendrons (PP-PLLD), is synthesized by the click reaction between azido-modified porphyrin and propargyl focal point poly(L-lysine) dendrons. Its chemical structure is characterized by 1H nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography (GPC) is analyses etc. Due to its amphiphilic property, the obtained PP-PLLD has a low critical micelle concentration in an aqueous solution, and can load d...
Last. Crispin R. Dass(VU: Victoria University, Australia)H-Index: 62
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Objectives The frontline drug doxorubicin has been used for treating cancer for over 30 years. While providing a cure in select cases, doxorubicin causes toxicity to most major organs, especially life-threatening cardiotoxicity, which forces the treatment to become dose-limiting. Key findings Doxorubicin is known to bind to DNA-associated enzymes, intercalate with DNA base pairs, and target multiple molecular targets to produce a range of cytotoxic effects. For instance, it causes the activation...
Last. Xiuju Zhang(JNU: Jinan University)H-Index: 3
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Abstract In order to improve the stability and decrease the cytotoxicity of silver nanoparticle (AgNP), a polyethyleneimine-modified reduced graphene oxide (PEI-rGO) was used as the substrate of AgNPs, and a PEI-rGO–AgNP hybrid was prepared by anchoring the AgNPs on the reduced graphene oxide surface. Such a hybrid showed substantially higher antibacterial activity than polyvinyl pyrrolidone (PVP)-stabilized AgNP, and the AgNPs on PEI-rGO were more stable than the AgNPs on PVP, resulting in long...
Last. Zhenyou Jiang(JNU: Jinan University)H-Index: 3
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Silver nanoparticles (AgNPs) are increasingly used in daily life for their antibacterial properties, but their low stability and high cytotoxicity hamper practical applications. In this work, sodium 1-naphthalenesulfonate-functionalized reduced graphene oxide (NA-rGO) was used as a substrate for AgNPs to produce a AgNP-NA-rGO hybrid. This hybrid showed substantially higher antibacterial activity than polyvinyl pyrrolidone(PVP)-stabilized AgNPs, and the AgNPs on NA-rGO were more stable than the A...
Graphene is a single-atom thick, two-dimensional sheet of hexagonally arranged carbon atoms isolated from its three-dimensional parent material, graphite. Related materials include few-layer-graphene (FLG), ultrathin graphite, graphene oxide (GO), reduced graphene oxide (rGO), and graphene nanosheets (GNS). This review proposes a systematic nomenclature for this set of Graphene-Family Nanomaterials (GFNs) and discusses specific materials properties relevant for biomolecular and cellular interact...
Last. Hua Zhang(NTU: Nanyang Technological University)H-Index: 166
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Graphene has attracted tremendous research interest in recent years, owing to its exceptional properties. The scaled-up and reliable production of graphene derivatives, such as graphene oxide (GO) and reduced graphene oxide (rGO), offers a wide range of possibilities to synthesize graphene-based functional materials for various applications. This critical review presents and discusses the current development of graphene-based composites. After introduction of the synthesis methods for graphene a...
#1Virendra Singh(UCF: University of Central Florida)H-Index: 23
#2Daeha Joung(UCF: University of Central Florida)H-Index: 16
Last. Sudipta Seal(UCF: University of Central Florida)H-Index: 96
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Abstract Graphene, a two dimensional monoatomic thick building block of a carbon allotrope, has emerged as an exotic material of the 21st century, and received world-wide attention due to its exceptional charge transport, thermal, optical, and mechanical properties. Graphene and its derivatives are being studied in nearly every field of science and engineering. Recent progress has shown that the graphene-based materials can have a profound impact on electronic and optoelectronic devices, chemica...
Last. Leong Huat Gan(NTU: Nanyang Technological University)H-Index: 21
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The covalent functionalization of graphene oxide (GO) with chitosan (CS) is successfully accomplished via a facile amidation process. The CS-grafted GO (GO–CS) sheets consist of about 64 wt.% CS, which imparts them with a good aqueous solubility and biocompatibility. Additionally, the physicochemical properties of GO–CS are studied. As a novel nanocarrier, GO–CS is applied to load a water-insoluble anticancer drug, camptothecin (CPT), via π–π stacking and hydrophobic interactions. It is demonstr...
Last. Laura J. Suggs(University of Texas at Austin)H-Index: 34
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Self-assembled nucleo-peptide hydrogels have a nanofibril structure composed of noncovalent molecular interactions between peptide groups as well as π–π stacking and Watson–Crick interactions via complementary nucleobases. These hydrogels have specific benefits for biomedical applications due to their DNA-like interactions in addition to the well-known advantages of peptide biomaterials: biocompatibility, extracellular matrix (ECM)-like structure, and bottom-up design. Inspired by the nucleobase...
Intranasal glucocorticoid spray is the preferred method to treat allergic rhinitis. However, due to the instantaneous high drug concentration, there are still some side effects, such as nasal dryness, nasal bleeding and even systemic effect of glucocorticoid. Herein, a novel biocompatible poly(methacrylic acid) (PMAA) nanogel was synthesized and used to load anti-IL-1β IgY (IgY) for treating allergic rhinitis induced by ovalbumin. The results indicated that PMAA nanogel had sustained-released ef...
Last. Kwok Feng Chong(Universiti Malaysia Pahang)H-Index: 28
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Graphene oxide (GO) possesses excellent mechanical strength, biocompatibility, colloidal stability, large surface area and high adsorption capability. It has driven to cancer nanotechnology to defeat cancer therapy obstacles, via integration into three-dimensional (3D) hydrogel network with biocompatible polymers as nanocomposites carrier, and controllable release of anticancer drugs. Specifically, the surface of GO affords π-π stacking and hydrophilic interactions with anticancer drugs. Additio...
#1Mengdi Zhou(Hangzhou Normal University)H-Index: 2
#2Qiyin Shen(Hangzhou Normal University)H-Index: 1
Last. Lijun Liang(Hangzhou Dianzi University)H-Index: 17
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Abstract Due to the unique structural and mechanical properties, graphene quantum dots (GQDs) are considered as potential candidates in the field of biosensors, bioimaging, and drug delivery etc. In this work, the adsorption of protein villin headpiece (HP35) on GQDs with different sizes was investigated by molecular dynamics simulations. The simulation results identified the key role of the π-π stacking interactions between the aromatic residues of HP35 and GQDs as the binding site. More import...
AIM: To build up a remote triggering drug delivery system with hyperthermia-responsive ammonium bicarbonate salt and investigate its effects on tumor therapy. MATERIALS & METHODS: This hybrid nanocapsule system was prepared by a different strategy, doxorubicin (DOX) was encapsulated in the heparin shell first and then ammonium bicarbonate was diffused into the nanocapsules to generate DOX-bicarbonate salt, its characterizations and effects on tumor therapy were investigated. RESULTS: Upon exposu...
Abstract As a promising drug carrier, graphene oxide (GO) has been studied widely in drug delivery due to its excellent loading ability to aromatic drugs. However, its biocompatibility, such as stability and blood compatibility, is now the biggest obstacle for its further application. Herein, the hyperbranched polyglycerol (HPG)-modified GO was prepared through the anionic ring-opening polymerization using GO as the initiator directly, and then the doxorubicin hydrochloride was loaded and showed...
Abstract In order to realize the controlled release and limited toxicity of triclosan (TC), a degradable UV-crosslinked hydrogel was prepared. For this purpose, the acryloyl chloride-modified polyactide-poly(ethylene glycol)-polylactide block copolymer was firstly synthesized and then mixed with photoinitiator to form the hydrogel rapidly under a low-intensity UV light. The properties of hydrogel, such as hydrogel strength, swelling and degradation, had been studied. The results showed that the ...
#2Xinyu Zhang(Southern Medical University)H-Index: 1
Last. Guohui Nie(PKU: Peking University)H-Index: 9
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Abstract The co-delivery of drug and gene has become the primary strategy in cancer therapy. However, to construct one safe co-delivering system with higher drug loading and gene transfection efficiency for cancer therapy is still challenging. Herein, a novel degradable nanocarriers were synthesized and characterized in this study, which was composed of polyethylenimine (PEI)-linked PEO–PPO–PEO (Pluronic F127), called F127-PEI. Then the nanocarrier was used for hydrophobic docetaxel (DOC) and fu...