Original paper
Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice
Abstract
PTEN is a dual lipid/protein phosphatase, downregulated in steatotic livers with obesity or HCV infection. Liver-specific PTEN knockout (LPTEN KO) mice develop steatosis, inflammation/fibrosis and hepatocellular carcinoma with aging, but surprisingly also enhanced glucose tolerance. This study aimed at understanding the mechanisms by which hepatic PTEN deficiency improves glucose tolerance, while promoting fatty liver diseases.Control and LPTEN...
Paper Details
Title
Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice
Published Date
Feb 1, 2015
Journal
Volume
62
Issue
2
Pages
421 - 429
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Notes
History