Patches of Disorganization in the Neocortex of Children with Autism

Autism involves early brain overgrowth and dysfunction, which is most strongly evident in the prefrontal cortex. As assessed on pathological analysis, an excess of neurons in the prefrontal cortex among children with autism signals a disturbance in prenatal development and may be concomitant with abnormal cell type and laminar development.To systematically examine neocortical architecture during the early years after the onset of autism, we used...