Oncogenic MST1R activity in pancreatic and gastric cancer represents a valid target of HSP90 inhibitors.
Abstract
To evaluate the effects of HSP90 blockade by EC154 on the oncogenic receptor tyrosine kinase macrophage-stimulating 1 receptor (MST1R) in gastric and pancreatic cancer.Impact of EC154 on signaling pathways was investigated by western blotting. Cancer cell migration was evaluated in Boyden chambers. Transcriptional regulation of MST1R was examined by using promoter-luciferase reporter constructs. Effects on MST1R expression, and tumor growth were...
Paper Details
Title
Oncogenic MST1R activity in pancreatic and gastric cancer represents a valid target of HSP90 inhibitors.
Published Date
Feb 1, 2012
Journal
Volume
32
Issue
2
Pages
427 - 37
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Notes
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