Oliver Stoeltzing
University of Hamburg
Receptor tyrosine kinaseCancerEndothelial stem cellInternal medicineEndocrinologyPathologyVascular endothelial growth factor AIn vivoVascular endothelial growth factorNeovascularizationMetastasisPancreatic cancerAngiogenesisCancer researchColorectal cancerSignal transductionMedicineProtein kinase BBiologyCancer cell
80Publications
44H-index
4,382Citations
Publications 79
Newest
#1Andreas GaumannH-Index: 24
#2Hannes C.A. Drexler (MPG: Max Planck Society)H-Index: 28
Last. Georg Breier (MPG: Max Planck Society)H-Index: 49
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Leiomyosarcomas remain challenging tumors to manage and novel therapy strategies besides radiation and conventional chemotherapy are needed. Targeting angiogenesis by inhibition of vascular endothelial growth factor (VEGF) receptor tyrosine kinases (RTKs) of the tumor vasculature with small molecules is a promising new therapy. It has been shown recently that these receptors are not only expressed on tumor endothelium but also on tumor cells themselves. Thus, we investigated the expression of me...
8 CitationsSource
#1Jung Sun Park (Chonnam National University)H-Index: 11
#2Pham Ngoc Khoi (Chonnam National University)H-Index: 11
Last. Young Do Jung (Chonnam National University)H-Index: 39
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: Abnormal accumulation and activation of the recepteur d'origine nantais (RON) has been implicated in epithelial tumor carcinogenesis. In the present study, we examined the effect of epigallocatechin-3-gallate (EGCG), the major green tea catechin, on the induction of RON and tumor growth in human gastric cancer. EGCG inhibited phorbol 12-myristate 13-acetate (PMA)-induced RON expression and reduced RON transcriptional activity. However, (-)-epigalloca-techin (EGC), (-)-epicatechin gallate (ECG)...
13 CitationsSource
#1Christian Moser (University of Regensburg)H-Index: 19
#2Petra Ruemmele (University of Regensburg)H-Index: 22
Last. Sven A. Lang (University of Regensburg)H-Index: 30
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The prognosis of patients suffering from pancreatic cancer is still poor and novel therapeutic options are urgently needed. Recently, the transcription factor signal transducer and activator of transcription 5b (STAT5b) was associated with tumor progression in human solid cancer. Hence, we assessed whether STAT5b might serve as an anticancer target in ductal pancreatic adenocarcinoma (DPAC). We found that nuclear expression of STAT5b can be detected in approximately 50% of DPAC. Blockade of STAT...
26 CitationsSource
#1Christian MoserH-Index: 19
#2Sven A. LangH-Index: 30
Last. Oliver StoeltzingH-Index: 44
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Aim: To evaluate the impact of heat-shock protein 90 (HSP90) blockade by the novel inhibitor NVP-AUY922, on tumor growth and angiogenesis in pancreatic cancer. Materials and Methods: Effects of NVP-AUY922 on signaling pathways were evaluated by western blotting. Cell motility of cancer cells, pericytes and endothelial cells was investigated in Boyden chambers. Impact of HSP90 blockade on pancreatic tumor growth and angiogenesis were studied in in vivo tumor models. Results: NVP-AUY922 effectivel...
30 Citations
#1Christian Moser (University of Regensburg)H-Index: 19
#2Sven A. LangH-Index: 30
Last. Oliver StoeltzingH-Index: 44
view all 13 authors...
Aim: To evaluate the effects of HSP90 blockade by EC154 on the oncogenic receptor tyrosine kinase macrophage-stimulating 1 receptor (MST1R) in gastric and pancreatic cancer. Materials and Methods: Impact of EC154 on signaling pathways was investigated by western blotting. Cancer cell migration was evaluated in Boyden chambers. Transcriptional regulation of MST1R was examined by using promoter-luciferase reporter constructs. Effects on MST1R expression, and tumor growth were investigated in in vi...
8 Citations
#1Christian MoserH-Index: 19
#2Petra RuemmeleH-Index: 22
Last. Sven Arke LangH-Index: 2
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The prognosis of patients suffering from pancreatic cancer is still poor and novel therapeutic options are urgently needed. Recently, the transcription factor signal transducer and activator of transcription 5b (STAT5b) was associated with tumor progression in human solid cancer. Hence, we assessed whether STAT5b might serve as an anticancer target in ductal pancreatic adenocarcinoma (DPAC). We found that nuclear expression of STAT5b can be detected in approximately 50% of DPAC. Blockade of STAT...
#1Johannes Taeger (University of Regensburg)H-Index: 1
#2Christian MoserH-Index: 19
Last. Sven A. Lang (University of Regensburg)H-Index: 30
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Activation of receptor tyrosine kinases (RTKs) such as fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR) and vascular-endothelial growth factor receptor (VEGFR) have been implicated in tumor progression and metastasis in human pancreatic cancer. In this study we investigated the effects of TKI258, a tyrosine kinase inhibitor to FGFR, PDGFR and VEGFR on pancreatic cancer cell lines (HPAF-II, BxPC-3, MiaPaCa-2, L3.6pl), endothelial cells (ECs) and vascular s...
108 CitationsSource
#1Sven A. Lang (University of Regensburg)H-Index: 30
#2Christian Moser (University of Regensburg)H-Index: 19
Last. Hans J. Schlitt (University of Regensburg)H-Index: 66
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Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL The transcription factor STAT5b (signal transducer and activator of transcription 5b) is implicated in tumor growth and metastases in various cancer entities including breast and prostate cancer. Activation of STAT5 signaling can be mediated via oncogene mutation (e.g. src kinase), cytokines (e.g. IL-6) and growth factors (e.g. EGF). So far, the role of STAT5b in human pancreatic adenocarcinoma (HPAC) has not been elucidate...
Source
217 Background: Activation of signal transducer and activator of transcription 5b (STAT5b) has been associated with tumor growth and metastases in various tumor entities. A number of cytokines, growth factors, and oncogenes that can induce STAT5b activity are also implicated in pancreatic cancer growth and metastases. Hence, we sought to determine STAT5b expression in human pancreatic cancer specimen and effects of selective STAT5b inhibition on pancreatic cancer cells. Methods: Expression of ST...
Source
#1Christina Hackl (University of Regensburg)H-Index: 16
#2Sven A. Lang (University of Regensburg)H-Index: 30
Last. Oliver Stoeltzing (University of Regensburg)H-Index: 44
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Background Activating transcription factor-3 (ATF3) is involved in the complex process of cellular stress response. However, its exact role in cancer is discussed controversially because both tumor suppressive and oncogenic effects have been described. Here we followed-up on our previous observation that inhibition of Hsp90 may increase ATF3 expression and sought to determine the role of ATF3 in colon cancer.
58 CitationsSource