Genetic Variation in the Antioxidant Gene Superoxide Dismutase 2 ( SOD2 ) and Response to Radiation Therapy (RT) for Prostate Cancer (PCa)

Germline genetic variation in antioxidant genes may affect the therapeutic efficacy of RT by altering the pro-oxidant environment initiated by RT. SOD2 encodes a key enzyme involved in quenching reactive oxygen species. We examined the association between single nucleotide polymorphisms (SNPs) in the antioxidant gene, SOD2, and lethal PCa after RT. The study population included participants from two prospective cohorts, the Physicians' Health...