Protrusion‐guided extracellular vesicles mediate CD30 trans‐signalling in the microenvironment of Hodgkin's lymphoma

Classical Hodgkin's lymphoma ( cHL )‐affected lymphoid tissue contains only a few malignant Hodgkin and Reed–Sternberg ( HRS ) cells, which are disseminated within a massive infiltrate of reactive cells. In particular, the innate immune infiltrate is deemed to support tumour growth by direct cell–cell interaction. Since they are rarely found in close proximity to the malignant cells in situ , we investigated whether cHL ‐derived extracellular...