The Journal of Pathology
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#1Shinsuke Fujii (Kyushu University)H-Index: 17
#2Takuma Ishibashi (Kyushu University)
Last. Peter Morgan ('KCL': King's College London)H-Index: 31
view all 14 authors...
Ameloblastoma is an odontogenic neoplasm characterized by slow intraosseous growth with progressive jaw resorption. Recent reports have revealed that ameloblastoma harbours an oncogenic BRAF V600E mutation with mitogen-activated protein kinase (MAPK) pathway activation and described cases of ameloblastoma harbouring a BRAF V600E mutation in which patients were successfully treated with a BRAF inhibitor. Therefore, the MAPK pathway may be involved in the development of ameloblastoma; however, the...
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#1Nanor Sirab (PSL Research University)H-Index: 1
#2Damien Drubay (Université Paris-Saclay)H-Index: 10
Last. Cécile Reyes (PSL Research University)H-Index: 11
view all 18 authors...
Basal/Squamous (Ba/Sq) subtype represents an intrinsic and robust group in the consensus molecular classification of muscle-invasive bladder cancer (MIBC), with poor outcome and controversial chemosensitivity. We aimed to investigate the spectrum of intratumor heterogeneity (ITH) in Ba/Sq subtype. First, we validated a 29 gene NanoString codeset to predict Ba/Sq subtype for FFPE samples. We identified heterogeneous Ba/Sq tumors in a series of 331 MIBC FFPE samples using dual GATA3/KRT5/6 immunoh...
1 CitationsSource
#1Andrea Gangfuß (University of Duisburg-Essen)H-Index: 1
#2Artur Czech (Leibniz Institute for Neurobiology)
Last. Cordula Kiewert (Boston Children's Hospital)
view all 17 authors...
Recessive variants in WASHC4 are linked to intellectual disability complicated by poor language skills, short stature, and dysmorphic features. The protein encoded by WASHC4 is part of the Wiskott-Aldrich Syndrome Protein and SCAR Homolog family, colocalizes with actin in cells and promotes Arp2/3-dependent actin polymerization in vitro. Functional studies in a zebrafish model suggested that WASHC4 knockdown may also affect skeletal muscles by perturbing protein clearance. However, skeletal musc...
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#1Montserrat Carrascal (CSIC: Spanish National Research Council)H-Index: 29
#2Aina Areny-Balagueró (CSIC: Spanish National Research Council)
Last. Joaquín Abián (CSIC: Spanish National Research Council)H-Index: 38
view all 11 authors...
As acute pancreatitis progresses to the severe form, a life-threatening systemic inflammation is triggered. Although the mechanisms involved in this process are not yet well understood, it has been proposed that circulating exosomes may be involved in the progression of inflammation from the pancreas to distant organs. Here, the inflammatory capacity and protein profile of plasma exosomes obtained during the first 24 h of hospitalization of patients diagnosed with acute pancreatitis were charact...
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#1Bianca Grosser (University of Augsburg)
#2Marie-Isabelle Glückstein (University of Augsburg)
Last. Dmytro Vlasenko (Augsburg College)
view all 12 authors...
Compared to other malignancies, there is a lack of easy-to-evaluate biomarkers for gastric cancer, which is associated with an adverse clinical outcome in many cases. Here, we present Stroma AReactive Invasion Front Areas (SARIFA) as a new histological prognostic marker. We defined SARIFA as the direct contact between a cluster of tumor glands/cells comprising at least five tumor cells and inconspicuous surrounding adipose tissue at the invasion front. A total of 480 adenocarcinomas of the stoma...
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#1Philipp JurmeisterH-Index: 9
#2Niklas Wrede (Humboldt University of Berlin)
Last. Wolfgang D. Schmitt (Humboldt University of Berlin)H-Index: 27
view all 18 authors...
Cutaneous, ocular, and mucosal melanomas are histologically indistinguishable tumors that are driven by a different spectrum of genetic alterations. With current methods, identification of the site of origin of a melanoma metastasis is challenging. DNA methylation profiling has shown promise for the identification of the site of tumor origin in various settings. Here we explore the DNA methylation landscape of melanomas from different sites and analyze if different melanoma origins can be distin...
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#1Frederick Charles Campbell ('QUB': Queen's University Belfast)H-Index: 22
Distinct morphological subtypes of colorectal cancer (CRC) confer a bleak clinical outlook. In a recent issue of The Journal of Pathology, Onuma et al investigated morphological evolution of a highly fatal CRC subtype known as micropapillary cancer (MPC). This study enhances understanding of MPC biology including essential regulatory signals, cellular and multicellular phenotypes, as well as cancer behaviour. Iterative modelling in three-dimensional (3D) patient-derived CRC tissue-originated sph...
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#1Seung-Hyun Jung (Catholic University of Korea)H-Index: 20
#2Hyeon-Chun Park (Catholic University of Korea)H-Index: 5
Last. Sug Hyung Lee (Catholic University of Korea)H-Index: 71
view all 6 authors...
Germ cell tumors (GCTs) originate during the histogenesis of primordial germ cells to mature gametes. Previous studies identified five histogenic mechanisms in ovarian mature teratomas (type I: failure of meiosis I; type II: failure of meiosis II; type III: duplication of the genome of a mature gamete; type IV: no meiosis; and type V: fusion of two different ova), but those of other GCTs remain elusive. In this study, we analyzed 84 GCTs of various pathologic types to identify the histogenesis u...
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#1Peter L. Schrammen (RWTH Aachen University)H-Index: 2
#2Narmin Ghaffari Laleh (RWTH Aachen University)
Last. Elizabeth Alwers (DKFZ: German Cancer Research Center)H-Index: 7
view all 19 authors...
Deep learning is a powerful tool in computational pathology: it can be used for tumor detection and for predicting genetic alterations based on histopathology images alone. Conventionally, tumor detection and prediction of genetic alterations are two separate workflows. Newer methods have combined them, but require complex, manually engineered computational pipelines, restricting reproducibility and robustness. To address these issues, we present a new method for simultaneous tumor detection and...
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#1Jeffrey Boschman (UBC: University of British Columbia)H-Index: 1
#2Hossein Farahani (UBC: University of British Columbia)H-Index: 8
Last. Steven J.M. JonesH-Index: 141
view all 15 authors...
The color variation of hematoxylin and eosin (HE pleural cancer: 0.21 AUC increase, p = 1.4 e-10). Furthermore, we introduce a novel augmentation strategy by mixing color-normalized images using three easily accessible algorithms that consistently improves the diagnosis of test images from external centers, even when the individual normalization methods had varied results. We anticipate our study to be a starting point for reliable use of color normalization to improve AI-based, digital patholog...
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Cancer
Pathology
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Immunohistochemistry
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