T-Dependent Antigen Response (TDAR) Tests: Meta-Analysis of Results Generated Across Multiple Laboratories

The primary T-cell-dependent antibody response (TDAR) to antigens is widely used as a functional test in immunotoxicology. TDAR assays can be performed using different antigens, e.g., sheep red blood cells (SRBC) and keyhole limpet hemocyanin (KLH) are presently utilized by different laboratories. The purpose of this study was to apply meta-analysis to compare data from several laboratories using these antigens, in two strains of rats, by...