Freeze-Dried Mannitol for Superior Pulmonary Drug Delivery via Dry Powder Inhaler

Published on Feb 1, 2013in Pharmaceutical Research4.2
路 DOI :10.1007/S11095-012-0892-4
Waseem Kaialy23
Estimated H-index: 23
(UKC: University of Kent),
Ali Nokhodchi63
Estimated H-index: 63
(UKC: University of Kent)
Sources
Abstract
Purpose To show for the first time the superior dry powder inhaler (DPI) performance of freeze dried mannitol in comparison to spray dried mannitol and commercial mannitol.
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#2Amjad Alhalaweh (Lule氓 University of Technology)H-Index: 22
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This study provides, for the first time, an evaluation of the physicochemical properties of batch cooling crystallized mannitol particles combined with how these properties correlated with the inhalation performance from a dry powder inhaler (Aerolizer). The results showed that the type of polymorph changed from 尾-form (commercial mannitol) to mixtures of 尾- + 未-mannitol (cooling crystallized mannitol crystals). In comparison to mannitol particles, crystallized at a higher supersaturation degree...
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Purpose To co-crystallise mannitol and lactose with a view to obtaining crystals with more favourable morphological features than either lactose or mannitol alone, suitable for use as carriers in formulations for dry powder inhalers (DPIs) using simultaneous engineering of lactose-mannitol mixtures.
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Abstract The purpose of this study was to evaluate the relationships between physicochemical properties and aerosolisation performance of different grades of lactose. In order to get a wide range of physicochemical properties, various grades of lactose namely Flowlac 庐 100 (FLO), Lactopress anhydrous 庐 250 (LAC), Cellactose 庐 80 (CEL), Tablettose 庐 80 (TAB), and Granulac 庐 200 (GRA) were used. The different lactose grades were carefully sieved to separate 63鈥90聽渭m particle size fractions and the...
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Drug delivery by inhalation has been routinely used for the treatment of localized diseases such as asthma and COPD. In addition to local delivery the pulmonary route has more recently been found to be a suitable for delivering of drugs for the treatment of systemic diseases, such as diabetes. Pressured metered dose inhaler (pMDI) have historically been the main device platform for delivering to the lung, however in the last two decades the dry powder inhaler (DPI) has become much more popular. ...
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Abstract Dry powder formulations are often composed of fine drug particles and coarser carrier particles, typically alpha-lactose monohydrate. However, the performance of a powder formulation may be highly dependent on the lactose quality and source. This study investigated the characteristics of lactose that influence the drug-to-carrier interaction and the performance of lactose-based dry powder inhaler formulations. The selected lactoses differed in the preparation processes and the content o...
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