Purpose
To show for the first time the superior dry powder inhaler (DPI) performance of freeze dried mannitol in comparison to spray dried mannitol and commercial mannitol.
#1Waseem Kaialy(Medway School of Pharmacy)H-Index: 23
#2Amjad Alhalaweh(Luleå University of Technology)H-Index: 22
Last. Ali Nokhodchi(Tabriz University of Medical Sciences)H-Index: 63
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The purpose of this study was to evaluate the effect of carrier particle size on properties of dry powder and its effect on dry powder inhaler (DPI) performance. Commercial α-lactose-monohydrate, a commonly used carrier in DPI formulations, was carefully sieved to obtain different lactose size fractions, namely Lac A (90-125μm), Lac B (63-90μm), Lac C (45-63μm), Lac D (20-45μm), and Lac E (<20μm). The lactose samples were analysed in terms of size, shape, solid state, density, and flowability. L...
Last. Ali Nokhodchi(UKC: University of Kent)H-Index: 63
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This study provides, for the first time, an evaluation of the physicochemical properties of batch cooling crystallized mannitol particles combined with how these properties correlated with the inhalation performance from a dry powder inhaler (Aerolizer). The results showed that the type of polymorph changed from β-form (commercial mannitol) to mixtures of β- + δ-mannitol (cooling crystallized mannitol crystals). In comparison to mannitol particles, crystallized at a higher supersaturation degree...
#2Lucia Prota(UNISA: University of Salerno)H-Index: 7
Last. Paola Russo(UNISA: University of Salerno)H-Index: 24
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Abstract The high hygroscopicity of gentamicin (G) as raw material hampers the production of respirable particles during aerosol generation and prevents its direct use as powder for inhalation in patients suffering from cystic fibrosis (CF). Therefore, this research aimed to design a new dry powder formulation of G studying dispersibility properties of an aminoacid, l -leucine (leu), and appropriate process conditions. Spray-dried powders were characterized as to water uptake, particle size dist...
Last. Ali Nokhodchi(UKC: University of Kent)H-Index: 63
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Purpose To co-crystallise mannitol and lactose with a view to obtaining crystals with more favourable morphological features than either lactose or mannitol alone, suitable for use as carriers in formulations for dry powder inhalers (DPIs) using simultaneous engineering of lactose-mannitol mixtures.
Last. M.P. Flament(French Institute of Health and Medical Research)H-Index: 2
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Abstract Due to their small size, the respirable drug particles tend to form agglomerates which prevent flowing and aerosolisation. A carrier is used to be mixed with drug in one hand to facilitate the powder flow during manufacturing, in other hand to help the fluidisation upon patient inhalation. Depending on drug concentration, drug agglomerates can be formed in the mixture. The aim of this work was to study the agglomeration behaviour of fluticasone propionate (FP) within interactive mixture...
Last. M.P. Flament(university of lille)H-Index: 10
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Interactions between particles are dependent on the physicochemical characteristics of the interacting particles but it is also important to consider the manufacturing process. Blending active pharmaceutical ingredient (API) with carrier is a critical stage that determines the blend homogeneity and is the first step towards obtaining the final quality of the powder blend. The aim of this work was to study parameters that influence the interactions between API and carrier in adhesive mixtures use...
#2Sin Hyen Kim(University of Texas at Austin)H-Index: 1
Last. Hugh D. C. Smyth(University of Texas at Austin)H-Index: 34
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Dry powder inhalers (DPIs) are distinguished from one another by their unique device geometries, reflecting their distinct drug detachment mechanisms, which can be broadly classified into either aerodynamic or mechanical-based detachment forces. Accordingly, pow- der particles experience different aerodynamic and mechanical forces depending on the in- haler. However, the influence of carrier particle physical properties on the performance of DPIs with different dispersion mechanisms remains larg...
Last. Ali Nokhodchi(Tabriz University of Medical Sciences)H-Index: 63
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Abstract The purpose of this study was to evaluate the relationships between physicochemical properties and aerosolisation performance of different grades of lactose. In order to get a wide range of physicochemical properties, various grades of lactose namely Flowlac ® 100 (FLO), Lactopress anhydrous ® 250 (LAC), Cellactose ® 80 (CEL), Tablettose ® 80 (TAB), and Granulac ® 200 (GRA) were used. The different lactose grades were carefully sieved to separate 63–90 μm particle size fractions and the...
Drug delivery by inhalation has been routinely used for the treatment of localized diseases such as asthma and COPD. In addition to local delivery the pulmonary route has more recently been found to be a suitable for delivering of drugs for the treatment of systemic diseases, such as diabetes. Pressured metered dose inhaler (pMDI) have historically been the main device platform for delivering to the lung, however in the last two decades the dry powder inhaler (DPI) has become much more popular. ...
Last. M.P. Flament(university of lille)H-Index: 10
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Abstract Dry powder formulations are often composed of fine drug particles and coarser carrier particles, typically alpha-lactose monohydrate. However, the performance of a powder formulation may be highly dependent on the lactose quality and source. This study investigated the characteristics of lactose that influence the drug-to-carrier interaction and the performance of lactose-based dry powder inhaler formulations. The selected lactoses differed in the preparation processes and the content o...
Last. Rita Ambrus(University of Szeged)H-Index: 21
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Abstract null null Dry powder inhalers (DPIs) are already on market, however, none of the DPIs are present for the treatment of tuberculosis. Herein, isoniazid-loaded nanopowders were developed for the delivery to the deeper lung tissues, more precisely alveoli. Chitosan (CS), thiolated chitosan (TC), and mannosylated chitosan (MC) were used individually in conjugation with hyaluronic acid (HA) because of their affinity for the pulmonary epithelium and alveolar macrophages. Here, the densities, ...
#1Vivek Patel(MSU: Maharaja Sayajirao University of Baroda)H-Index: 24
#2Denish Bardoliwala(MSU: Maharaja Sayajirao University of Baroda)H-Index: 4
Last. Ambikanandan Misra(Narsee Monjee Institute of Management Studies)H-Index: 48
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Background: The current study sought to formulate a dry powder inhalant (DPI) for pulmonary delivery of lipopolymeric nanoparticles (LPNs) consisting of cisplatin and siRNA for multidrug-resistant ...
#2You-Yang Zhao(Children's Memorial Hospital)H-Index: 1
The pulmonary route has long been used for drug administration for both local and systemic treatment. It possesses several advantages, which can be categorized into physiological, i.e., large surface area, thin epithelial membrane, highly vascularized, limited enzymatic activity, and patient convenience, i.e., non-invasive, self-administration over oral and systemic routes of drug administration. However, the formulation of dry powder for pulmonary delivery is often challenging due to restrictio...
Last. K.H. Assi(University of Bradford)H-Index: 11
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Abstract Two different types of dry powder inhalers (Easyhaler® and RS01®) were used in this work to evaluate the ex vivo and in vitro performance of a budesonide inhaled formulation with recrystallised mannitol, commercial DPI-grade mannitol, or lactose. The aerodynamic performance of the budesonide formulation with recrystallised mannitol was superior when RS01® was used (FPF = 45.8%) compared to Easyhaler® (FPF = 14%). However, the aerodynamic profile was very poor in both devices when commer...
Last. Imran Saleem(LJMU: Liverpool John Moores University)H-Index: 20
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Abstract The treatment and management of COPD by inhalation to the lungs has emerged as an attractive alternative route to oral dosing due to higher concentrations of the drug being administered to site of action. In this study, Nanocomposite Microparticles (NCMPs) of microRNA (miR-146a) containing PGA-co-PDL nanoparticles (NPs) for dry powder inhalation were formulated using L-leucine and mannitol. The spray-drying (Buchi B290) process was optimised and used to incorporate NPs into NCMPs using ...
#2Waseem Kaialy(University of Wolverhampton)H-Index: 23
Last. Ali Nokhodchi(University of Sussex)H-Index: 63
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Generally, DPI formulations show low fine particle fraction (FPF) due to poor detachment of drug particles from carrier during inhalation. L-Leucine, with varying concentrations (ranging from 0 to 10% w/w), were introduced into a 60%w/v mannitol solution where the solutions were then spray dried to achieve a new processed carrier. The spray dried samples were blended with Albuterol sulfate to determine the efficacy of their aerosolization performance. Analyzing each formulation was completed via...
#3Jakub Szlęk(Jagiellonian University Medical College)H-Index: 10
Last. Raymond Lau(NTU: Nanyang Technological University)H-Index: 26
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Abstract In this work, design parameters of carrier-based dry powder inhalation were studied using surrogate modeling technique. The surrogate models constructed were then used to evaluate the key design parameters independently, which were otherwise difficult to determine based on experimental studies alone. Artificial neural network (ANN) was chosen as the surrogate modeling technique and models were constructed based on experimental data obtained from the literature. Twenty eight variables de...
: Dry powder inhalers are medical devices used to deliver powder formulations of active pharmaceutical ingredients via oral inhalation to the lungs. Drug particles, from a biological perspective, should reach the targeted site, dissolve and permeate through the epithelial cell layer in order to deliver a therapeutic effect. However, drug particle attributes that lead to a biological activity are not always consistent with the technical requirements necessary for formulation design. For example, ...
#2Waseem Kaialy(University of Wolverhampton)H-Index: 23
Last. Ali Nokhodchi(University of Sussex)H-Index: 63
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Spray-drying allows to modify the physicochemical/mechanical properties of particles along with their morphology. In the present study, L-leucine with varying concentrations (0.1, 0.5, 1, 5, and 10% w/v) were incorporated into lactose monohydrate solution for spray-drying to enhance the aerosolization performance of dry powder inhalers containing spray-dried lactose-leucine and salbutamol sulfate. The prepared spray-dried lactose-leucine carriers were analyzed using laser diffraction (particle s...
Chronic obstruction pulmonary disease (COPD) is a major cause of morbidity and mortality across the world. COPD is currently the fourth leading cause of death in the world and is predicted to become the third leading cause of chronic illness and death worldwide by 2030. There are several therapeutic strategies to reduce COPD symptoms and complications such as; bronchodilator medications, antibiotics, inhaled corticosteroids and rehabilitation. However, none of the available pharmacological or no...
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