Pharmaceutical Research
Papers 9,324
1 page of 933 pages (9,324 results)
#1Ji Muse (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Hongbing Liu (SPU: Shenyang Pharmaceutical University)H-Index: 3
Last. Xing Tang (SPU: Shenyang Pharmaceutical University)H-Index: 28
view all 10 authors...
The objective of the present study was to prepare stable and high bioavailability ocular atropine loaded films (ATR-films) as potential ocular drug delivery systems for the treatment of myopia. ATR-films were prepared by the solvent casting method and the physical properties of films were evaluated including thickness, water content, light transparency, disintegration time, and mechanical properties. FT-IR, DSC, XRD, TGA, AFM, and Raman spectroscopy were performed to characterize the film. The s...
#1Chang Ren (CPU: China Pharmaceutical University)H-Index: 4
#2Yao Wang (CPU: China Pharmaceutical University)H-Index: 2
Last. Xijing Chen (CPU: China Pharmaceutical University)H-Index: 22
view all 15 authors...
Sulcardine sulfate (Sul) is a novel antiarrhythmic agent with promising pharmacological properties, which is currently being evaluated in several clinical trials as an oral formulation. To meet the medication needs of patients with acute conditions, the injection formulation of Sul has been developed. The objective of this study was to systemically investigate the pharmacokinetic profiles of Sul after intravenous infusion. This research included the plasma protein binding and metabolic stability...
Diabetic nephropathy (DN), one of severe diabetic complications in the diabetes, is the main cause of end stage renal disease (ESRD). Notably, the currently available medications used to treat DN remain limited. Here, we determined whether berberine (BBR) could enhance the anti-diabetic nephropathy activities of metformin (Met) and explored its possible mechanisms. The anti-diabetic nephropathy properties were systematically analyzed in the diabetic db/db mice treated with Met, BBR or with combi...
#1Jun-Jun Mao (Fudan University)H-Index: 3
#2Xiaoyan Qiu (Fudan University)H-Index: 9
Last. Mingkang Zhong (Fudan University)H-Index: 17
view all 6 authors...
AIM The pharmacokinetic (PK) properties of cyclosporine (CsA) in renal transplant recipients are patient- and time-dependent. Knowledge of this time-related variability is necessary to maintain or achieve CsA target exposure. Here, we aimed to identify factors explaining variabilities in CsA PK properties and characterize time-varying clearance (CL/F) by performing a comprehensive analysis of CsA PK factors using population PK (popPK) modeling of long-term follow-up data from our institution. ME...
#1Shuaibing Liu (Zhengzhou University)H-Index: 2
#2Jasleen K. Sodhi (Plexxikon)H-Index: 10
Last. Leslie Z. Benet (UCSF: University of California, San Francisco)H-Index: 101
view all 3 authors...
Purpose null Previous studies evaluating ticagrelor drug-drug interactions have not differentiated intestinal versus systemic mechanisms, which we do here. null Methods null Using recently published methodologies from our laboratory to differentiate metabolic- from transporter-mediated drug-drug interactions, a critical evaluation of five published ticagrelor drug-drug interactions was carried out to investigate the purported clinical significance of enzymes and transporters in ticagrelor dispos...
#1Oliver Bluemel (LMU: Ludwig Maximilian University of Munich)H-Index: 1
#2Jakob Buecheler (Novartis)H-Index: 1
Last. Wolfgang Friess (LMU: Ludwig Maximilian University of Munich)H-Index: 53
view all 6 authors...
PURPOSE Scale-down devices (SDD) are designed to simulate large-scale thawing of protein drug substance, but require only a fraction of the material. To evaluate the performance of a new SDD that aims to predict thawing in large-scale 2 L bottles, we characterised 3D temperature profiles and changes in concentration and density in comparison to 125 mL and 2 L bottles. Differences in diffusion between a monoclonal antibody (mAb) and histidine buffer after thawing were examined. METHODS Temperatur...
#1Luyuan Li (CPU: China Pharmaceutical University)
#2Zunting Pang (CPU: China Pharmaceutical University)H-Index: 2
Last. Shuai Qian (CPU: China Pharmaceutical University)H-Index: 15
view all 8 authors...
PURPOSE This study aimed to improve the in vitro dissolution, permeability and oral bioavailability of adefovir dipivoxil (ADD) by cocrystal technology and clarify the important role of coformer selection on the cocrystal's properties. METHODS ADD was cocrystallized with three small molecules (i.e., paracetamol (PA), saccharin (SAC) and nicotinamide (NIC)), respectively. The obtained ADD-PA cocrystal was characterized by DSC, TGA, PXRD and FTIR. Comparative study on dissolution rates among the t...
#1Mariana Guimarães (University of Bath)H-Index: 1
#2Martin Kuentz (University of Applied Sciences and Arts Northwestern Switzerland FHNW)H-Index: 28
Last. Nikoletta Fotaki (University of Bath)H-Index: 18
view all 4 authors...
PURPOSE To understand drug solubilization as a function of age and identify drugs at risk of altered drug solubility in pediatric patients. To assess the discrimination ability of the Abraham solvation parameters and age-related changes in simulated media composition to predict in vitro drug solubility differences between pediatric and adult gastrointestinal conditions by multivariate data analysis. METHODS Differences between drug solubility in pediatric and adult biorelevant media were express...
#1Yajie Zhang (Regeneron)H-Index: 7
#2Melissa Soto (University of Texas at Austin)H-Index: 2
Last. Robert O. Williams (University of Texas at Austin)H-Index: 63
view all 4 authors...
Bacteriophage (phage) therapy has re-gained attention lately given the ever-increasing prevalence of multi-drug resistance ‘super-bugs’. To develop therapeutic phage into clinically usable drug products, the strategy of solidifying phage formulations has been implemented to diversify the dosage forms and to overcome the storage condition limitations for liquid phage formulations. In our work, we hypothesize and tested that an advanced technology, thin film freeze-drying (TFFD), can be used to pr...
#1Divan A. Burger (University of Pretoria)H-Index: 8
#2Robert Schall (University of the Free State)H-Index: 26
Last. Sean van der Merwe (University of the Free State)H-Index: 2
view all 3 authors...
In this paper, we propose a robust Bayesian method for the assessment of average bioequivalence based on data from conventional crossover studies. We evaluate and motivate empirically the need for robust methods in bioequivalence studies by comparing the results of robust and conventional statistical methods in a large data pool of bioequivalence studies. Robustness of the statistical methodology is achieved by replacing the normal distributions for residuals in the linear mixed model with skew-...
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