cAMP attenuates the enhanced expression of Giproteins and hyperproliferation of vascular smooth muscle cells from SHR: role of ROS and ROS-mediated signaling
Volume: 304, Issue: 12, Pages: C1198 - C1209
Published: Jun 15, 2013
Abstract
We previously showed that angiotensin II (ANG II)-induced overexpression of inhibitory G proteins (Gi) was attenuated by dibutyryl-cAMP (db-cAMP) in A10 vascular smooth muscle cells (VSMC). Since enhanced levels of endogenous ANG II contributed to the overexpression of Gi protein and hyperproliferation of VSMC from spontaneously hypertensive rats (SHR), the present study was therefore undertaken to examine if cAMP could also attenuate the...
Paper Details
Title
cAMP attenuates the enhanced expression of Giproteins and hyperproliferation of vascular smooth muscle cells from SHR: role of ROS and ROS-mediated signaling
Published Date
Jun 15, 2013
Volume
304
Issue
12
Pages
C1198 - C1209
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