American Journal of Physiology-cell Physiology
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#1Shawna L. McMillin (University of Minnesota)
#2Everett C Minchew (ECU: East Carolina University)
Last. Espen E. Spangenburg (ECU: East Carolina University)H-Index: 36
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The importance of defining sex differences across various biological and physiological mechanisms is more pervasive now than it has been over the last 15-20 years. As the muscle biology field pushes to identify small molecules and interventions to prevent, attenuate or even reverse muscle wasting, we must consider the effect of sex as a biological variable. It should not be assumed that a therapeutic will affect males and females with equal efficacy or equivalent target affinities under conditio...
#1Adriana M. Fresquez (RFUMS: Rosalind Franklin University of Medicine and Science)
#2Carl White (RFUMS: Rosalind Franklin University of Medicine and Science)H-Index: 22
The gaseous signaling molecule hydrogen sulfide (H2S) physiologically regulates store-operated Ca2+ entry (SOCE). The SOCE machinery consists of the plasma membrane-localized Orai channels (Orai1-3) and endoplasmic reticulum-localized STIM1 and STIM2 proteins. H2S inhibits Orai3- but not Orai1- or Orai2-mediated SOCE. The current objective was to define the mechanism by which H2S selectively modifies Orai3. We measured SOCE and STIM1/Orai3 dynamics and interactions in HEK293 cells exogenously ex...
#1Chwen-Lih Chen (NEOMED: Northeast Ohio Medical University)H-Index: 7
#2Liwen Zhang (OSU: The Ohio State University)H-Index: 25
Last. Yeong-Renn Chen (NEOMED: Northeast Ohio Medical University)H-Index: 13
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Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cellular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by complexes I and III of the electron transport chain (ETC) and by the proton motive force (PMF), consisting of a membrane potential (ΔΨ) and a proton gradient (ΔpH). Several factors control redox status in mitochondria, including ROS, the PMF, oxidative post-tra...
#1Bin Guo (PSU: Pennsylvania State University)H-Index: 2
#2Devasier Bennet (PSU: Pennsylvania State University)H-Index: 13
Last. Gustavo A. Nader (PSU: Pennsylvania State University)H-Index: 27
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Chemotherapeutic agents (CAs) are first-line antineoplastic treatments in a wide variety of cancers. These agents can induce oxidative stress and promote muscle loss. CAs trigger local and systemic...
#1Bingxuan Han (PKU: Peking University)H-Index: 2
#2Shuang Cui (PKU: Peking University)H-Index: 9
Last. Ming Yi (PKU: Peking University)H-Index: 15
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Thirst is an important interoceptive response and drives water consumption. The hippocampus actively modulates food intake and energy metabolism, but direct evidence for the exact role of the hippo...
#1Mohamed Zakaria Nassef (Technische Universität Braunschweig)
#2Jasmin E. Hanke (Technische Universität Braunschweig)H-Index: 1
Last. Karsten Hiller (Technische Universität Braunschweig)H-Index: 36
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Mitochondria are considered to be the powerhouse of the cell. Normal functioning of the mitochondria is not only essential for cellular energy production but also for several immunomodulatory processes. Macrophages operate in metabolic niches and rely on rapid adaptation to specific metabolic conditions such as hypoxia, nutrient limitations or reactive oxygen species to neutralize pathogens. In this regard, the fast reprogramming of mitochondrial metabolism is indispensable to provide the cells ...
#1Donato A. Rivas (Tufts University)H-Index: 19
#2Fei Peng (Tufts University)
Last. Lee M. Margolis (Tufts University)H-Index: 23
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Our laboratory has discovered that dysregulation in microRNA (miRNA) that target anabolic signaling between younger and older adults is a potential molecular mechanism resulting in age-associated d...
#1Ziyi Wang (GMU: Guangzhou Medical University)H-Index: 7
#2Jiyuan Chen (GMU: Guangzhou Medical University)H-Index: 3
Last. Jason X.-J. Yuan (UCSD: University of California, San Diego)H-Index: 74
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Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+ influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung vasculatu...
#1Michael Jennings (UAMS: University of Arkansas for Medical Sciences)H-Index: 42
The major transmembrane protein of the red blood cell, known as band 3, AE1, and SLC4A1, has two main functions: 1) catalysis of Cl-/HCO3- exchange, one of the steps in CO2 excretion; 2) anchoring ...
#1Peter Z. Schall (MSU: Michigan State University)H-Index: 5
#2Keith E. Latham (MSU: Michigan State University)H-Index: 52
The morula to blastocyst transition (MBT) culminates with formation of inner cell mass (ICM) and trophectoderm (TE) lineages. Recent studies identified signaling pathways driving lineage specificat...
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