A dose-response study of vitamin D3 supplementation in healthy Chinese: a 5-arm randomized, placebo-controlled trial.

Published on Feb 1, 2016in European Journal of Nutrition5.619
· DOI :10.1007/S00394-015-0859-4
Pang Yao6
Estimated H-index: 6
(CAS: Chinese Academy of Sciences),
Ling Lu27
Estimated H-index: 27
(CAS: Chinese Academy of Sciences)
+ 9 AuthorsLin Xu1
Estimated H-index: 1
(CAS: Chinese Academy of Sciences)
Sources
Abstract
Purpose To determine the dose–response of vitamin D3 supplementation on serum 25-hydroxyvitamin D [25(OH)D] among Chinese adults.
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2016
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References43
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#1Fabiana Viegas Raimundo (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 5
Last. Tania Weber Furlanetto (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 18
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Purpose This double-blind placebo-controlled trial evaluated serum 25-hydroxyvitamin D [25(OH)D] levels after the oral intake of a single dose of cholecalciferol during one of the three meals, containing different amounts of fat or placebo.
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#1Kimmie Ng (Harvard University)H-Index: 47
#2Jamil B. Scott (Harvard University)H-Index: 6
Last. Charles S. Fuchs (Harvard University)H-Index: 166
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Background: Association studies have suggested that lower circulating 25-hydroxyvitamin D [25(OH)D] in African Americans may partially underlie higher rates of cardiovascular disease and cancer in this population. Nonetheless, the relation between vitamin D supplementation and 25(OH)D concentrations in African Americans remains undefined. Objective: Our primary objective was to determine the doseresponse relation between vitamin D and plasma 25(OH)D. Design: A total of 328 African Americans in B...
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#1Francesca JarrettH-Index: 1
#2Gloria Michelle Ducasa (UNM: University of New Mexico)H-Index: 2
Last. Marianne BerwickH-Index: 75
view all 4 authors...
Due to the strong interest in the role of vitamin D in health, we tried to find data to illustrate the relationship between oral supplementation and change in serum levels of vitamin D. We reviewed the literature of randomized, placebo-controlled trials of oral supplementation and serum levels of vitamin D through 2014. We found 25 informative studies which showed a significant dose-response between oral supplementation and serum levels of vitamin D with an r2 of 0.61.These data are consistent w...
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#1Armin Zittermann (RUB: Ruhr University Bochum)H-Index: 63
#2Jana B. Ernst (RUB: Ruhr University Bochum)H-Index: 9
Last. Jochen Börgermann (RUB: Ruhr University Bochum)H-Index: 33
view all 4 authors...
Purpose There is considerable variation in incremental circulating 25-hydroxyvitamin D (25OHD) levels on vitamin D supplements, even when similar age groups and identical vitamin D doses are compared. We therefore aimed to investigate the importance of body weight for the dose–response relation in circulating 25OHD.
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#1J. Christopher Gallagher (Creighton University Medical Center)H-Index: 16
#2Prachi S Jindal (Creighton University Medical Center)H-Index: 2
Last. Lynette M. Smith (UNMC: University of Nebraska Medical Center)H-Index: 67
view all 3 authors...
There is limited information on the effects of vitamin D on serum 25 hydroxyvitamin D (25OHD) in young people and none on African Americans. The main objective of this trial was to measure the effect of different doses of vitamin D3 on serum 25OHD and serum parathyroid hormone (PTH) in young women with vitamin D insufficiency (serum 25OHD ≤ 20 ng/mL (50 nmol/L). A randomized double-blind placebo-controlled trial of vitamin D3 was conducted in young white and African American women, age 25 to 45 ...
Source
#1John P. FormanH-Index: 64
#2Jamil B. ScottH-Index: 6
Last. Andrew T. ChanH-Index: 116
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Blacks have significantly higher rates of hypertension than whites, and lower circulating levels of 25-hydroxyvitamin D. There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on blood pressure in blacks. During 2 winters from 2008 to 2010, 283 blacks (median age, 51 years) were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 international units of cholecalciferol per day. At baseline, 3 months, and 6 months, systolic and dias...
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#3A. Catharine RossH-Index: 49
#4Christine L TaylorH-Index: 15
Last. Heather B Del ValleH-Index: 5
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The charge to the committee (Institute of Medicine Committee to Review Dietary Reference Intakes for Vitamin D and Calcium) was to assess current relevant data and update, as appropriate, the DRIs (Dietary Reference Intakes) for vitamin D and calcium. The review was to include consideration of chronic disease indicators (e.g., reduction in risk of cancer) and other (non-chronic disease) indicators and health outcomes. The definitions of these terms are discussed below. Consistent with the framew...
#1J. Christopher Gallagher (Creighton University)H-Index: 30
#2Munro Peacock (IU: Indiana University)H-Index: 87
Last. Lynette M. Smith (UNMC: University of Nebraska Medical Center)H-Index: 67
view all 4 authors...
Context: Serum 25-hydroxyvitamin D (25OHD) is lower in women with darker skin color. Is it due to lower skin production, lower absorption, or different metabolism of vitamin D? Objectives: The objective of the study was to measure the effect of vitamin D3 on serum 25OHD and serum PTH in older African American women with vitamin D insufficiency and the serum 25OHD 20 ng/mL or less (<50 nmol/L). The results can be used to estimate the Recommended Dietary Allowance (RDA). Design and Setting: This w...
Source
#1Deborah M. Mitchell (Harvard University)H-Index: 13
#2Maria P HenaoH-Index: 4
view all 4 authors...
Objective: Vitamin D deficiency is highly prevalent in high-risk patient populations, but the prevalence among otherwise healthy adults is less well-defined. The goal of this study was to determine...
Source
#1Claudia Gagnon (Laval University)H-Index: 22
#2Zhong X. LuH-Index: 19
Last. Robin M. Daly (Deakin University)H-Index: 54
view all 9 authors...
Context: Serum 25-hydroxyvitamin D [25(OH)D] concentration has been inversely associated with the prevalence of metabolic syndrome (MetS), but the relationship between 25(OH)D and incident MetS remains unclear. Objective: We evaluated the prospective association between 25(OH)D, MetS, and its components in a large population-based cohort of adults aged 25 yr or older. Design: We used baseline (1999–2000) and 5-yr follow-up data of the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab). ...
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Cited By9
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#1Kai Lun Hu (ZJU: Zhejiang University)
#2Kwanghann Gan (ZJU: Zhejiang University)
Last. Dan Zhang (ZJU: Zhejiang University)H-Index: 24
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Introduction Polycystic ovary syndrome (PCOS) is one of the leading causes of female infertility, affecting around 5% of women of childbearing age in China. Vitamin D insufficiency is common in women with PCOS and is associated with lower live birth rates. However, evidence regarding the effectiveness of vitamin D supplementation in women with PCOS is inconclusive. This multicentre randomised, double-blinded, placebo-controlled trial aims to evaluate the effectiveness of vitamin D supplementatio...
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#1Jeane Franco Pires Medeiros (UFRN: Federal University of Rio Grande do Norte)H-Index: 4
#2Michelle Vasconcelos de Oliveira Borges (UFRN: Federal University of Rio Grande do Norte)H-Index: 2
Last. André Ducati Luchessi (UFRN: Federal University of Rio Grande do Norte)H-Index: 17
view all 13 authors...
Vitamin D supplementation is widely used. However, there is no consensus on the use and dosage of this supplement and the existing recommendations arise from studies based on the benefits that this nutrient can facilitate in bones. In addition, individual genetics can influence the response to supplementation, therefore, research involving monozygotic twins aims to reduce these differences in phenotypic responses. The objective of this randomised controlled study is to examine the effect of vita...
Source
#3Marion Mafham (Clinical Trial Service Unit)H-Index: 12
#7R. J. Clarke (Clinical Trial Service Unit)H-Index: 123
Importance Vitamin D and calcium supplements are recommended for the prevention of fracture, but previous randomized clinical trials (RCTs) have reported conflicting results, with uncertainty about optimal doses and regimens for supplementation and their overall effectiveness. Objective To assess the risks of fracture associated with differences in concentrations of 25-hydroxyvitamin D (25[OH]D) in observational studies and the risks of fracture associated with supplementation with vitamin D alo...
Source
#1Nasser M. Al-Daghri (KSU: King Saud University)H-Index: 60
#2Abdul Khader Mohammed (UOS: University of Sharjah)H-Index: 17
Last. Majed Alokail (UOS: University of Sharjah)H-Index: 1
view all 11 authors...
Abstract Objectives The aim of this study was to determine the influence of vitamin D–binding protein (DBP) gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation. Methods In all, 234 participants (126 women; 108 men) with vitamin D deficiency [25(OH)D Results Baseline 25(OH)D was significantly in higher in participants with homozygous major genotype of rs7041 than other genotypes (P = 0.02). Postsupplementation 25(OH)D was significantly higher in participants wit...
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#1Minjia Mo (ZJU: Zhejiang University)H-Index: 7
#2Shijie Wang (ZJU: Zhejiang University)H-Index: 1
Last. Yunxian Yu (ZJU: Zhejiang University)H-Index: 18
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Optimal doses of vitamin D (VitD) supplement in different populations are unclear. We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [25(OH)D] concentration, to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different populations. Literature search was conducted in Embase, etc. Randomized controlled trials about VitD supplemental intakes and their effect on 25(OH)D concentration were enrolled....
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#1Pang Yao (CAS: Chinese Academy of Sciences)H-Index: 6
#2Liang Sun (CAS: Chinese Academy of Sciences)H-Index: 39
Last. Xu Lin (CAS: Chinese Academy of Sciences)H-Index: 28
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BACKGROUND: Bone turnover markers (BTMs) are proposed as alternative indicators for bone mineral density in diagnosis and management of osteoporosis. However, little is known about the effects of vitamin D supplementation on BTMs in nonwhite populations. OBJECTIVE: We aimed to investigate the responses in BTMs after vitamin D supplementation in Asians. METHODS: In this secondary data analysis of a randomized, double-blind, placebo-controlled trial, 448 Chinese adults [mean ± SD age: 31.9 ± 8.0 y...
Source
#1Pang YaoH-Index: 6
#2Liang SunH-Index: 39
Last. Xu LinH-Index: 28
view all 19 authors...
Context: Little is known how genetic and non-genetic factors modify responses of vitamin D supplementation in nonwhite populations. Objective: To investigate factors modifying 25-hydroxyvitamin D (25[OH]D) and bioavailable 25(OH)D (25[OH]DBio) responses after vitamin D3 supplementation. Design, Setting, Participants, and Intervention: In this randomized, double-blinded, placebo-controlled trial, 448 Chinese with vitamin D deficiency (25[OH]D<50 nmol/L) received 2000 IU/d vitamin D3 or placebo fo...
Source
#1Xiaoyan Xiao (SDU: Shandong University)H-Index: 2
#2Yajuan Wang (SDU: Shandong University)H-Index: 3
Last. Zhao Hu (SDU: Shandong University)H-Index: 1
view all 6 authors...
ObjectivesTo investigate serum 25-hydroxyvitamin D (25[OH]D) levels in patients with diabetic nephropathy, analyse the relationship between 25(OH)D and clinical indexes, and identify risk factors for vitamin D deficiency in diabetic nephropathy.MethodsPatients with diabetic nephropathy were sequentially enrolled and grouped according to diabetic nephropathy stage. Serum 25(OH)D levels were measured. A control group of healthy subjects was used for comparison.ResultsOut of 240 patients with diabe...
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