Original paper
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Abstract
Diabetes and obesity are two metabolic diseases characterized by insulin resistance and a low-grade inflammation. Seeking an inflammatory factor causative of the onset of insulin resistance, obesity, and diabetes, we have identified bacterial lipopolysaccharide (LPS) as a triggering factor. We found that normal endotoxemia increased or decreased during the fed or fasted state, respectively, on a nutritional basis and that a 4-week high-fat diet...
Paper Details
Title
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Published Date
Jul 1, 2007
Journal
Volume
56
Issue
7
Pages
1761 - 1772
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Notes
History