Evaluation of acute bronchodilator reversibility in patients with symptoms of GOLD stage I COPD

Patients with symptoms of GOLD stage I chronic obstructive pulmonary disease (COPD) can have significant abnormalities of ventilatory mechanics with greater exertional symptoms and exercise limitation than age-matched healthy subjects. In such patients the impact of bronchodilator therapy remains unknown and is difficult to evaluate.The acute effects of nebulised ipratropium bromide 500 microg (IB) on resting pulmonary function and on dyspnoea...