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#1Pallavi Bedi (University of Edinburgh)H-Index: 7
#2Kerstin Ziegler (UHI: University of the Highlands and Islands)
Last. Adam T. Hill (University of Edinburgh)H-Index: 57
view all 6 authors...
Introduction null Bronchiectasis is characterised by excessive neutrophilic inflammation. Lipid mediators such as prostaglandins and leukotrienes have crucial roles in the inflammatory response. Further characterisation of these lipids and understanding the interplay of anti-inflammatory and proinflammatory lipid mediators could lead to the development of novel anti-inflammatory therapies for bronchiectasis. null Aim null The aim of our study was to characterise the lipids obtained from serum an...
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#1Rishi K Gupta (UCL: University College London)H-Index: 15
#2Maarten van Smeden (OSU-CHS: Oklahoma State University Center for Health Sciences)H-Index: 3
The field of prediction modelling has exploded during the COVID-19 pandemic, with countless studies seeking to derive and/or validate models to assist diagnosis of SARS-CoV-2 or to predict clinical outcomes of infection. While the vast majority of reports have been of a poor standard,1 there have been some examples of higher quality work, including the QCOVID prognostic model.2 Whereas most prediction models are intended to predict a single outcome, QCOVID seeks to predict the risk of acquiring ...
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#1Colin R SimpsonH-Index: 37
#2Chris Robertson (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 1
Last. Aziz SheikhH-Index: 139
view all 15 authors...
BACKGROUND: The QCovid algorithm is a risk prediction tool that can be used to stratify individuals by risk of COVID-19 hospitalisation and mortality. Version 1 of the algorithm was trained using data covering 10.5 million patients in England in the period 24 January 2020 to 30 April 2020. We carried out an external validation of version 1 of the QCovid algorithm in Scotland. METHODS: We established a national COVID-19 data platform using individual level data for the population of Scotland (5.4...
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#1Sébastien Baillieul (UGA: Grenoble Alpes University)H-Index: 8
#2Sébastien Bailly (UGA: Grenoble Alpes University)H-Index: 19
Last. Renaud Tamisier (UGA: Grenoble Alpes University)H-Index: 46
view all 9 authors...
Rationale null Sleep-disordered breathing (SDB) is highly prevalent after stroke. The clinical and ventilatory chemosensitivity characteristics of SDB, namely obstructive, central and coexisting obstructive and central sleep apnoea (coexisting sleep apnoea) following stroke are poorly described. null Objective null To determine the respective clinical and ventilatory chemosensitivity characteristics of SDB at least 3 months after a first ischaemic stroke. null Methods null Cross-sectional analys...
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#1Andrew Bush (NIH: National Institutes of Health)H-Index: 114
#2Rishi PabaryH-Index: 4
The finding of granulomas on paediatric tissue biopsy is non-specific, with a wide differential diagnosis that includes chronic infection (eg, tuberculous, atypical Mycobacterium infection, leprosy, Lyme disease, brucellosis, syphilis and histoplasmosis), immunodeficiency (hyper-IgM syndrome, chronic granulomatous disease), connective tissue disease (juvenile chronic arthritis) and miscellaneous conditions such as Blau’s syndrome, Melkersson-Rosenthal syndrome, Anderson-Fabry disease and Vogt-Ko...
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#1David T Arnold (University of Bristol)H-Index: 17
#2Fergus Hamilton (North Bristol NHS Trust)H-Index: 12
Last. Ed Moran (North Bristol NHS Trust)H-Index: 12
view all 3 authors...
The COVID-19 pandemic has led to the widespread use of continuous positive airway pressure (CPAP) and high flow nasal oxygen systems (HFNO) for respiratory support, with the former recently shown to reduce the requirement for intubation and mechanical ventilation, easing pressure on intensive care and improving outcomes.1 One major concern remains the theoretical risk for aerosolisation of SARS-CoV-2, with both CPAP and HFNO currently considered ‘aerosol generating procedures’ (AGPs). This class...
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The paper by Thomsen et al 1 is a significant contribution to the now-substantial body of literature on the relationship between asbestos-related diseases and vehicle repair work. It is a large study, inclusive of all registered vehicle mechanics in the country for the designated years, with a mean follow-up time of 20 years and a maximum of 45 years. Several comprehensive administrative databases were linked for exposure and disease outcomes. The numbers of outcomes for the three main diseases ...
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#1Fergus Hamilton (University of Bristol)H-Index: 12
#2Florence K. A. Gregson (University of Bristol)H-Index: 9
Last. James W. Dodd (University of Bristol)H-Index: 14
view all 13 authors...
INTRODUCTION: continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) provide enhanced oxygen delivery and respiratory support for patients with severe COVID-19. CPAP and HFNO are currently designated as aerosol-generating procedures despite limited high-quality experimental data. We aimed to characterise aerosol emission from HFNO and CPAP and compare with breathing, speaking and coughing. MATERIALS AND METHODS: Healthy volunteers were recruited to breathe, speak and cough ...
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#1Rebecca L Winslow (UHB: University Hospitals Birmingham NHS Foundation Trust)H-Index: 1
#2Jie Zhou (Imperial College London)H-Index: 12
Last. Christopher A Green (University of Birmingham)H-Index: 27
view all 17 authors...
Background null Continuous positive airways pressure (CPAP) and high-flow nasal oxygen (HFNO) are considered ‘aerosol-generating procedures’ in the treatment of COVID-19. null Objective null To measure air and surface environmental contamination with SARS-CoV-2 virus when CPAP and HFNO are used, compared with supplemental oxygen, to investigate the potential risks of viral transmission to healthcare workers and patients. null Methods null 30 hospitalised patients with COVID-19 requiring suppleme...
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#1Sadiyah Sheikh (University of Bristol)H-Index: 4
#2Fergus HamiltonH-Index: 12
Last. James W. Dodd (North Bristol NHS Trust)H-Index: 14
view all 11 authors...
Pulmonary function tests are fundamental to the diagnosis and monitoring of respiratory diseases. There is uncertainty around whether potentially infectious aerosols are produced during testing and there are limited data on mitigation strategies to reduce risk to staff. Healthy volunteers and patients with lung disease underwent standardised spirometry, peak flow and FENO assessments. Aerosol number concentration was sampled using an aerodynamic particle sizer and an optical particle sizer. Meas...
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