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#2Laura HarmacekH-Index: 5
Last. Sonia M. LeachH-Index: 17
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The prognostic value of peripheral blood mononuclear cell (PBMC) expression profiles, when used in patients with chronic hypersensitivity pneumonitis (CHP), as an adjunct to traditional clinical assessment is unknown. RNA-seq analysis on PBMC from 37 patients with CHP at initial presentation determined that (1) 74 differentially expressed transcripts at a 10% false discovery rate distinguished those with (n=10) and without (n=27) disease progression, defined as absolute FVC and/or diffusing capa...
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#1Tess Kramer (UvA: University of Amsterdam)H-Index: 1
#2Lizzy Wijmans (UvA: University of Amsterdam)H-Index: 5
Last. Jouke T. Annema (UvA: University of Amsterdam)H-Index: 34
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Introduction null Diagnosing peripheral lung cancer with the bronchoscope is challenging with near miss of the target lesion as major obstacle. Needle-based confocal laser endomicroscopy (nCLE) enables real-time microscopic tumour visualisation at the needle tip (smart needle). null Aim null To investigate feasibility and safety of bronchoscopic nCLE imaging of suspected peripheral lung cancer and to assess whether nCLE imaging allows real-time discrimination between malignancy and airway/lung p...
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#1Anaïs Hérivaux (University of Minho)
#2Jesse R. WillisH-Index: 6
Last. Cristina Cunha (University of Minho)H-Index: 30
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Rationale null Recent studies have revealed that the lung microbiota of critically ill patients is altered and predicts clinical outcomes. The incidence of invasive fungal infections, namely, invasive pulmonary aspergillosis (IPA), in immunocompromised patients is increasing, but the clinical significance of variations in lung bacterial communities is unknown. null Objectives null To define the contribution of the lung microbiota to the development and course of IPA. null Methods and measurement...
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#1Aya M Abbas (Wexham Park Hospital)
#2Kate Brackenborough (Wexham Park Hospital)
Last. Safoora Rehman (Wexham Park Hospital)
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A 44-year-old Polish man attended the emergency department complaining of cough and pleuritic chest pain. He had a fever of 38.6°C and his oxygen saturation (SpO2) was 97%. His medical history included childhood asthma. He took no medication or over-the-counter remedies. He was a smoker with a 60-pack year history and consumed 200 units of alcohol a week for 16 years, but reported he stopped drinking 1 month ago. He migrated from Poland 15 years ago and worked as a manual labourer. He denied any...
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#1Céline ForsterH-Index: 1
Last. Michel ChristodoulouH-Index: 8
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A 47-year-old woman was diagnosed with pelvic endometriosis during a caesarean at the age of 37 years. Two years later, she presented two episodes of spontaneous right-sided pneumothorax occurring 2 days after the onset of her menses. The first episode was treated with pleural drainage and the chest CT scan did not show parenchymal or diaphragmatic anomalies. A second episode occurred 1 month later and the patient underwent thoracoscopic exploration, wedge resection of the lung apex and mechanic...
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#1Auyon J. Ghosh (Brigham and Women's Hospital)H-Index: 6
#2Aabida Saferali (Brigham and Women's Hospital)H-Index: 9
Last. Craig P. Hersh (Brigham and Women's Hospital)H-Index: 53
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Rationale null COPD can be assessed using multidimensional grading systems with components from three domains: pulmonary function tests, symptoms and systemic features. Clinically, measures may be used interchangeably, though it is not known if they share similar pathobiology. null Objective null To use RNA sequencing (RNA-seq) to determine if there is an overlap in the underlying biological mechanisms and consequences driving different components of the multidimensional grading systems. null Me...
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#1Shiu Lun Au Yeung (HKU: University of Hong Kong)H-Index: 15
#2Maria Carolina Borges (UoB: University of Bristol)H-Index: 18
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Introduction null Observational studies suggested lung function is inversely associated with cardiovascular disease (CVD) although these studies could be confounded. We conducted a two sample Mendelian randomisation study using summary statistics from genome-wide association studies (GWAS) to clarify the role of lung function in CVD and its risk factors, and conversely the role of CVD in lung function. null Methods null We obtained genetic instruments for forced expiratory volume in 1 s (FEV1: 2...
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#1Yutong Cai (University of Oxford)H-Index: 12
Children are particularly vulnerable to airborne pollutants due to their immature lungs and immune system. Many studies have reported deleterious effects of exposure to ambient air pollution, in acute or chronic timeframe, on respiratory health in children.1 Airborne pollen are microscopic grains that are released from trees, grasses and weeds. Ample epidemiological evidence has suggested associations between high airborne pollen count and emergency hospital visits for allergies and asthma exace...
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#1Hannah Lee Grimes (University of Cambridge)
#2Simon HoldenH-Index: 10
Last. Eamonn R. Maher (University of Cambridge)H-Index: 139
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Familial spontaneous pneumothorax (FSP) accounts for 10% of primary spontaneous pneumothoraces. Appropriate investigation of FSP enables early diagnosis of serious monogenic diseases and the practice of precision medicine. Here, we show that a pneumothorax genetics multidisciplinary team (MDT) can efficiently diagnose a range of syndromic causes of FSP. A sizeable group (73.6%) of clinically unclassifiable FSPs remains. Using whole genome sequencing we demonstrate that most of these cases are no...
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#1Vadsala Baskaran (NUH: Nottingham University Hospitals NHS Trust)H-Index: 3
#2Wei Shen Lim (NUH: Nottingham University Hospitals NHS Trust)H-Index: 37
Last. Tricia M. McKeever (NIHR: National Institute for Health Research)H-Index: 53
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The incidence of and risk factors for recurrent hospitalisation for pneumonia were investigated using data from Hospital Episode Statistics, linked to a UK primary care database. Within 90 days and 1 year of follow-up, 1733 (3.1%) and 5064 (9.0%), developed recurrent pneumonia respectively. Smoking status at the time of hospitalisation with index pneumonia was associated with the risk of readmission with recurrent pneumonia within a year of discharge: current versus never smokers: adjusted subha...
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