Pooled Efficacy Results From Two Multinational Randomized Controlled Clinical Trials of a Single Intravitreous Injection of Highly Purified Ovine Hyaluronidase (Vitrase®) for the Management of Vitreous Hemorrhage

To evaluate the efficacy of intravitreous ovine hyaluronidase for the management of vitreous hemorrhage.Two prospective, randomized, placebo-controlled, double-masked studies. Safety data are presented in a companion article in The Journal.Eligible patients with vitreous hemorrhage > or = 1 month duration; severe at entry with best corrected visual acuity (BCVA) worse than 20/200 were randomized to 55 IU or 75 IU ovine hyaluronidase or saline....