Increased Levels of Interleukin-1 Are Detected in Nasal Secretions of Volunteers during Experimental Rhinovirus Colds

The potential involvement of interleukin-1 (IL-1) in the pathogenesis of experimental rhinovirus colds was examined. Nasal lavages were recovered before and for 5 days after rhinovirus infection from 44 subjects, 22 of whom were randomized to receive prophylaxis with glucocorticoids, while the rest received placebo. Immunoreactive IL-1 beta was significantly increased in subjects who were infected and symptomatic compared with noninfected...