David Proud
University of Calgary
AirwayProvocation testHistamineInternal medicineChemokineEndocrinologyMolecular biologyProinflammatory cytokineChemistryImmunologyIn vivoAllergyAsthmaInflammationRhinovirusEpitheliumCXCL10MedicineBiologyRespiratory epitheliumCell biology
149Publications
75H-index
5,016Citations
Publications 288
Newest
Human rhinoviruses (HRV) are common cold viruses associated with exacerbations of lower airways diseases. Although viral induced epithelial damage mediates inflammation, the molecular mechanisms responsible for airway epithelial damage and dysfunction remain undefined. Using experimental HRV infection studies in highly differentiated human bronchial epithelial cells grown at air-liquid interface (ALI), we examine the links between viral host defense, cellular metabolism, and epithelial barrier f...
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#1Aubrey N. Michi (U of C: University of Calgary)H-Index: 4
#2David Proud (U of C: University of Calgary)H-Index: 75
Submerged cultures of primary human airway epithelial cells, or human airway epithelial cell lines have been a mainstay of airway epithelial biology research for decades due to their robust in vitro proliferative capacity, relatively low maintenance culture conditions, and clinically translatable results to nasal or bronchial brushings. With the development and improvement of air-liquid interface (ALI) cultures of human airway epithelial cells, such cultures have been considered superior to immo...
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#1Shahina Wiehler (U of C: University of Calgary)H-Index: 18
#2David Proud (U of C: University of Calgary)H-Index: 75
Human rhinovirus infections are a major trigger for acute exacerbations of lower airway diseases, including asthma and chronic obstructive pulmonary disease. Disease exacerbation is thought to be regulated via double-stranded RNA (dsRNA)-mediated signaling of proinflammatory and host defense responses in airway epithelial cells. Despite the central role of dsRNA in regulating host cell responses, no method for the quantitative assessment of dsRNA levels during HRV infections has been developed. ...
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#1Mahmoud M. Mostafa (U of C: University of Calgary)H-Index: 11
#2Akanksha Bansal (U of C: University of Calgary)
Last. Robert Newton (U of C: University of Calgary)H-Index: 65
view all 7 authors...
Ligand-activated glucocorticoid receptor (GR) elicits variable glucocorticoid-modulated transcriptomes in different cell types. However, some genes, including Kruppel-like factor 9 (KLF9), a putative transcriptional repressor, demonstrate conserved responses. We show that glucocorticoids induce KLF9 expression in the human airways in vivo and in differentiated human bronchial epithelial (HBE) cells grown at air-liquid interface (ALI). In A549 and BEAS-2B pulmonary epithelial cells, glucocorticoi...
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#1Aubrey N. MichiH-Index: 4
#2Michelle E. LoveH-Index: 2
Last. David ProudH-Index: 75
view all 3 authors...
Human rhinoviruses have been linked both to the susceptibility of asthma development and to the triggering of acute exacerbations. Given that the human airway epithelial cell is the primary site of human rhinovirus (HRV) infection and replication, the current review focuses on how HRV-induced modulation of several aspects of epithelial cell phenotype could contribute to the development of asthma or to the induction of exacerbations. Modification of epithelial proinflammatory and antiviral respon...
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#1Ran Wang (UQ: University of Queensland)H-Index: 11
#2David Proud (U of C: University of Calgary)H-Index: 75
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#1Cameron D. Griffiths (U of A: University of Alberta)H-Index: 4
#2Leanne M. Bilawchuk (U of A: University of Alberta)H-Index: 5
Last. David J. Marchant (U of A: University of Alberta)H-Index: 11
view all 18 authors...
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#1Cameron D. Griffiths (U of A: University of Alberta)H-Index: 4
#2Leanne M. Bilawchuk (U of A: University of Alberta)H-Index: 5
Last. David J. Marchant (U of A: University of Alberta)H-Index: 11
view all 18 authors...
Pneumonia resulting from infection is one of the leading causes of death worldwide. Pulmonary infection by the respiratory syncytial virus (RSV) is a large burden on human health, for which there are few therapeutic options1. RSV targets ciliated epithelial cells in the airways, but how viruses such as RSV interact with receptors on these cells is not understood. Nucleolin is an entry coreceptor for RSV2 and also mediates the cellular entry of influenza, the parainfluenza virus, some enterovirus...
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#1M. Love (U of C: University of Calgary)
#2Shahina Wiehler (U of C: University of Calgary)H-Index: 18
Last. David Proud (U of C: University of Calgary)H-Index: 75
view all 4 authors...
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#1D. Pham (U of C: University of Calgary)
#2Cora Kooi (U of C: University of Calgary)H-Index: 19
Last. Richard Leigh (U of C: University of Calgary)H-Index: 42
view all 5 authors...
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