Glutamine preconditioning protects against local and systemic injury induced by orthopaedic surgery

Long bone surgery represents a significant surgical insults, and may cause severe local and systemic sequalae following both planned and emergent surgery. Glutamine offers pharmacological modulation of injury through clinically acceptable preconditioning. This effect has not been previously demonstrated in an orthopaedic model. The aim of the study was to test the hypothesis that glutamine preconditioning protects against the local and systemic...