David Bouchier-Hayes
Royal College of Surgeons in Ireland
EndocrinologySurgeryPathologyApoptosisImmunologyHeat shock proteinVascular endothelial growth factorTaurineAngiogenesisIrishLaparotomyLung injuryAnesthesiaCancer researchIschemiaGeneral surgeryMedicineBiologyGastroenterologyPharmacology
427Publications
67H-index
10.3kCitations
Publications 416
Newest
#1Angela DuffyH-Index: 7
Last. Judith H. HarmeyH-Index: 24
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28 Citations
#1Michael Scully (RCSI: Royal College of Surgeons in Ireland)H-Index: 3
#2Chen Gang (RCSI: Royal College of Surgeons in Ireland)H-Index: 3
Last. Anthony J. Cunningham (RCSI: Royal College of Surgeons in Ireland)H-Index: 8
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Background Polymorphoneutrophils (PMNs) are activated by inflammatory mediators following splanchnic ischemia/reperfusion (I/R), potentially injuring organs such as the lung. As a result, some patients develop respiratory failure following abdominal aortic aneurysm repair. Pulmonary cyclooxygenase (COX)-2 protects against acid aspiration and bacterial instillation via lipoxins, a family of potent anti-inflammatory lipid mediators. We explored the role of COX-2 and lipoxin A 4 in experimental I/R...
12 CitationsSource
#1Colin G. Murphy (RCSI: Royal College of Surgeons in Ireland)H-Index: 1
#2R. Stapelton (NUI: National University of Ireland)H-Index: 1
Last. David Bouchier-Hayes (RCSI: Royal College of Surgeons in Ireland)H-Index: 67
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Introduction Long bone surgery represents a significant surgical insults, and may cause severe local and systemic sequalae following both planned and emergent surgery. Glutamine offers pharmacological modulation of injury through clinically acceptable preconditioning. This effect has not been previously demonstrated in an orthopaedic model.
1 CitationsSource
#1Ayman Osman Nasr (RCSI: Royal College of Surgeons in Ireland)H-Index: 1
#2Mary F. Dillon (RCSI: Royal College of Surgeons in Ireland)H-Index: 14
Last. Thomas N. Walsh (RCSI: Royal College of Surgeons in Ireland)H-Index: 29
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Background The contribution of gastric acid to the toxicity of alkaline duodenal refluxate on the esophageal mucosa is unclear. This study compared the effect of duodenal refluxate when acid was present, decreased by proton pump inhibitors (PPI), or absent. Methods We randomized 136 Sprague-Dawley rats into 4 groups: group 1 (n = 33) were controls; group 2 (n = 34) underwent esophagoduodenostomy promoting “combined reflux”; group 3 (n = 34) underwent esophagoduodenostomy and PPI treatment to dec...
16 CitationsSource
#1Rory KennellyH-Index: 12
#2John B. ConneelyH-Index: 3
Last. Desmond C. WinterH-Index: 45
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Mast cells are largely found at interfaces between the environment and the internal milieu. Early knowledge of the mast cell suggested a role predominantly associated with allergy and pathologic response to antigens, but more recent research has shown a myriad of functions is likely. Wound healing is a complex process of lysis and reconstitution controlled by a series of cell signalling proteins. Mast cells have been shown to play a significant role in the early inflammatory stage of wound heali...
19 CitationsSource
#1Michael A. Moloney (Beaumont Hospital)H-Index: 4
#2Seamus McHugh (Beaumont Hospital)H-Index: 13
Last. David Bouchier-Hayes (Beaumont Hospital)H-Index: 67
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Backgound Abdominal aortic aneurysm (AAA) surgery provides a unique opportunity to study the impact of arterial stiffness on central haemodynamics, reflected in augmentation index (AI). The aneurysmal aorta is significantly stiffer than undilated age-matched aorta.
10 CitationsSource
#1Rory KennellyH-Index: 12
#2John B. Conneely (Beaumont Hospital)H-Index: 3
Last. Desmond C. WinterH-Index: 45
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Introduction Hypoperfusion of the bowel is a risk factor for anastomotic failure. Electrical field stimulation has been shown to improve repair in ischemic tissue, but its influence in hypoperfused colon has not been investigated. The hypothesis of this experimental animal study was that electrical field stimulation improves anastomotic healing in ischemic bowel.
20 CitationsSource
#1J. B. O’Sullivan (RCSI: Royal College of Surgeons in Ireland)H-Index: 1
#2Richard Hanson (RCSI: Royal College of Surgeons in Ireland)H-Index: 3
Last. David Bouchier-Hayes (RCSI: Royal College of Surgeons in Ireland)H-Index: 67
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Background Diabetes mellitus is a leading cause of impaired wound healing. The aim of this study was to establish a glucose-controlled diabetic wound healing model.
6 CitationsSource
#1John Coneely (RCSI: Royal College of Surgeons in Ireland)H-Index: 1
#2Rory KennellyH-Index: 12
Last. Desmond C. WinterH-Index: 45
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Background Mast cell degranulation is an important step in early wound healing in the skin however the role of the mast cell in anastomotic healing is less clear. The aim of this study was to investigate the importance of mast cell degranulation in anastomotic healing and to assess whether a promoter of mast cell degranulation could increase anastomotic healing in poorly perfused bowel. Methods Fifty Wistar rats were divided into five groups: control, normally perfused bowel with mast cell stabi...
10 CitationsSource
#1Kishore K. Doddakula (Cork University Hospital)H-Index: 2
#2Peter M. Neary (Cork University Hospital)H-Index: 8
Last. Henry Paul Redmond (Cork University Hospital)H-Index: 58
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Background Cardiopulmonary bypass results in ischemia/reperfusion (I/R)-induced endotoxemia. We conducted a prospective randomized trial to investigate the effect of taurolidine, an antiendotoxin agent with antioxidant and membrane-stabilizing properties, on patients undergoing coronary artery bypass grafting (CABG). Methods A total of 60 patients undergoing CABG were randomized into 4 groups. St Thomas' Hospital cold crystalloid cardioplegia was used in groups A and B, and cold blood cardiopleg...
10 CitationsSource