Pneumothorax in two siblings: Is there a genetic basis for recurrence?

The incidence of primary pneumothorax is reported as 18 to 28 per 100,000 per year for men and 1.2 to 6 per 100,000 per year for women, with approximately 10% having a positive family history.1 Although recurrent pneumothoraces on the ipsilateral side is seen in less than 5% of cases and may be dependent on the surgical technique, contralateral recurrence may arise because of individual or familial predisposition. Autosomal dominant inheritance...