PNVCL-PEGMA nanohydrogels with tailored transition temperature for controlled delivery of 5-fluorouracil

Sensitive nanohydrogels were prepared via surfactant free emulsion copolymerization of N ‐vinylcaprolactam and poly(ethylene glycol) methyl ether methacrylate, and either N ‐vinylpyrrolidone (VP) or 2‐methacryloyloxybenzoic acid (2MBA) to adjust the transition temperature ( T tr ). The crosslinker ethylene glycol dimethacrylate was used for the polymer network construction. The resulting nanohydrogel sizes are between 120 and 300 nm. ρ...