Systematic identification of genomic markers of drug sensitivity in cancer cells
Abstract
Clinical responses to anticancer therapies are often restricted to a subset of patients. In some cases, mutated cancer genes are potent biomarkers for responses to targeted agents. Here, to uncover new biomarkers of sensitivity and resistance to cancer therapeutics, we screened a panel of several hundred cancer cell lines--which represent much of the tissue-type and genetic diversity of human cancers--with 130 drugs under clinical and...
Paper Details
Title
Systematic identification of genomic markers of drug sensitivity in cancer cells
Published Date
Mar 1, 2012
Journal
Volume
483
Issue
7391
Pages
570 - 575
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