Attenuation of Allergen-Induced Responses in CCR6−/− Mice Is Dependent upon Altered Pulmonary T Lymphocyte Activation

We have established a defect in CCR6−/− mice in response to a cockroach allergen airway challenge characterized by decreased IL-5 production, reduced CD4+ T and B cells as well as decreased eosinophil accumulation. To determine the nature of the defect in CCR6−/− mice T lymphocyte populations from allergen-sensitized wild-type mice were transferred into sensitized CCR6−/− mice. The reconstituted response was characterized by an increase in IL-5...