Cyclohexene, diketopiperazine, lactone and phenol derivatives from the sea fan-derived fungi Nigrospora sp. PSU-F11 and PSU-F12

Published on Mar 30, 2010in Archives of Pharmacal Research2.934
· DOI :10.1007/S12272-010-0305-3
Vatcharin Rukachaisirikul34
Estimated H-index: 34
(PSU: Prince of Songkla University),
Nanthaphong Khamthong6
Estimated H-index: 6
(PSU: Prince of Songkla University)
+ 5 AuthorsKanyawim Kirtikara26
Estimated H-index: 26
Nigrosporanenes A (1) and B (2), two new cylohexene derivatives, and tyrosol (3) were isolated from the sea fan-derived fungus Nigrospora sp. PSU-F11, whereas five known compounds: 4-hydroxybenzoic acid (4), aplysiopsene D (5), 3-isochromanone (6), (−)-drimenin (7) and diketopiperazine derivative (8), were obtained from the fungus Nigrospora sp. PSU-F12. Their structures were established by spectroscopic evidence. We also tested their cytotoxic (on African green monkey kidney fibroblast and breast cancer cells), antioxidant (in the DPPH assay), and antibacterial (against the standard Staphylococcus aureus ATCC 25923 and methicillinresistant S. aureus) activities.
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