Archives of Pharmacal Research
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#1Myeonghoon Song (Kyung Hee University)
#2Taeyoung Koo (Kyung Hee University)H-Index: 17
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#1Aadrita Hazra (BIT Mesra: Birla Institute of Technology, Mesra)
#2Pritha Bose (BIT Mesra: Birla Institute of Technology, Mesra)H-Index: 5
Last. Shakti P. Pattanayak (RMIT: RMIT University)H-Index: 2
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Breast cancer has become one of the most common dreadful diseases that target women across the globe. The most obvious reasons we associate with it are either genetic mutations or dysregulation of pathways. However, there is yet another domain that has a significant role in influencing the genetic mutations and pathways. Epigenetic mechanisms influence these pathways either independently or in association with genetic mutations, thereby expediting the process of breast carcinogenesis. Breast can...
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#1Mao Deng (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 3
#2Huijuan Chen (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 3
Last. Xiaofang Li (CDUTCM: Chengdu University of Traditional Chinese Medicine)H-Index: 6
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Atractylodes macrocephala Koidz is a widely used as a traditional Chinese medicine. Atractylenolides (-I, -II, and -III) are a class of lactone compounds derived from Atractylodes macrocephala Koidz. Research into atractylenolides over the past two decades has shown that atractylenolides have anti-cancer, anti-inflammatory, anti-platelet, anti-osteoporosis, and antibacterial activity; protect the nervous system; and regulate blood glucose and lipids. Because of structural differences, both atrac...
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#1Sapna Thakur (Central University of Punjab)H-Index: 5
#2Sonu Kumar Gupta (Central University of Punjab)H-Index: 3
Last. Malkhey Verma (BHU: Banaras Hindu University)H-Index: 1
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Diabetes mellitus, a disorder of metabolism, results in the elevation of glucose level in the blood. In this hyperglycaemic condition, aldose reductase overexpresses and leads to further complications of diabetes through the polyol pathway. Glucose metabolism-related disorders are the accumulation of sorbitol, overproduction of NADH and fructose, reduction in NAD+, and excessive NADPH usage, leading to diabetic pathogenesis and its complications such as retinopathy, neuropathy, and nephropathy. ...
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#1Hyesu Jeon (CNU: Chungnam National University)H-Index: 1
#2Yujin Jin (CNU: Chungnam National University)H-Index: 3
Last. Kyung-Sun Heo (CNU: Chungnam National University)H-Index: 20
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In this study, we investigated the anti-cancer effects of ginsenoside Rg2 (G-Rg2) and its underlying signaling pathways in breast cancer (BC) cells. G-Rg2 significantly induced cytotoxicity and reactive oxygen species (ROS) production in MCF-7 cells among various types of BC cells including HCC1428, T47D, and BT-549. G-Rg2 significantly inhibited protein and mRNA expression of cell cycle G1-S phase regulators, including p-Rb, cyclin D1, CDK4, and CDK6, whereas it enhanced the protein and mRNA ex...
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#1Sujata Purja (CAU: Chung-Ang University)H-Index: 1
#2Hocheol Shin (CAU: Chung-Ang University)H-Index: 1
Last. Eun Young Kim (CAU: Chung-Ang University)H-Index: 25
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Anecdotal evidence suggests that the severity of coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is likely to be distinguished by variations in loss of smell (LOS). Thus, we conducted a meta-analysis of 45 articles that include a total of 42,120 COVID-19 patients from 17 different countries to demonstrate that severely ill or hospitalized COVID-19 patients have a lesser chance of experiencing LOS than non-severely ill or non-hospita...
1 CitationsSource
#1Younghoon Kim (SKKU: Sungkyunkwan University)H-Index: 13
#2Pureum Kang (SKKU: Sungkyunkwan University)H-Index: 2
Last. Seok-Yong Lee (SKKU: Sungkyunkwan University)H-Index: 30
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Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) and a representative selective cyclooxygenase (COX)-2 inhibitor, which is commonly prescribed for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain, and primary dysmenorrhea. It is mainly metabolized by CYP2C9 and partly by CYP3A4 after oral administration. Many studies reported that CYP2C9 genetic polymorphism has significant effects on the pharmacokinetics of celecoxib and the occurrence of adverse drug reaction...
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#1Eun-Joo Shin (Kangwon National University)H-Index: 35
#2Ji Hoon Jeong (CAU: Chung-Ang University)H-Index: 62
Last. Toshitaka Nabeshima (Fujita Health University)H-Index: 96
view all 11 authors...
Parkinson’s disease (PD) is a progressive neurodegenerative disease with a high prevalence, approximately 1 % in the elderly population. Numerous studies have demonstrated that methamphetamine (MA) intoxication caused the neurological deficits and nigrostriatal damage seen in Parkinsonian conditions, and subsequent rodent studies have found that neurotoxic binge administration of MA reproduced PD-like features, in terms of its symptomatology and pathology. Several anti-Parkinsonian medications h...
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#1Young-Jung Lee (Cheju Halla University)H-Index: 3
#2In Jun Yeo (CBNU: Chungbuk National University)H-Index: 7
Last. Jin Tae Hong (CBNU: Chungbuk National University)H-Index: 63
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Human immunodeficiency virus 1 (HIV-1) infection can cause several HIV-associated neurocognitive disorders a variety of neurological impairments characterized by the loss of cortical and subcortical neurons and decreased cognitive and motor function. HIV-1 gp120, the major envelope glycoprotein on viral particles, acts as a binding protein for viral entry and is known to be an agent of neuronal cell death. To determine the mechanism of HIV-1 gp120-induced memory dysfunction, we performed mouse i...
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Recent studies have shown that pre and postconditioning the heart with sodium thiosulfate (STS) attenuate ischemia–reperfusion (IR) injury. However, the underlying mechanism involved in the cardioprotective signaling pathway is not fully explored. This study examined the existing link of STS mediated protection (as pre and post-conditioning agents) with PI3K, mTOR, and mPTP signaling pathways using its respective inhibitors. STS was administered to the isolated perfused rat heart through Kreb’s ...
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