When apparent diffusion coefficient (ADC) parameters are determined from whole-lesion histogram analysis, the 10th percentile ADC correlates better with the Gleason score and enables more accurate differentiation of prostate cancer lesions with a Gleason score of 6 from those with a Gleason score of at least 7 than do other ADC parameters commonly used in the literature.
The findings of this retrospective study suggest that computer-aided diagnosis based on a combination of quantitative imaging features derived from multiparametric endorectal MR images might be effective in distinguishing prostate cancer from normal prostate tissue and that apparent diffusion coefficient features and volume transfer constant moderately correlate with tumor Gleason score.
In the differentiation between aggressiveness classes, the combination of the apparent diffusion coefficient, choline plus creatine-to-citrate ratio, and cholineto-creatine ratio by means of a logistic regression model did not result in better differentiation than any of the three individual variables.
What's known on the subject? and What does the study add? Active surveillance for prostate cancer is gaining increasing acceptance for low risk prostate cancer. Focal therapy is an emerging tissue preservation strategy that aims for treat only areas of cancer. Early phase trials have shown that side-effects can be significantly reduced using focal therapy. There is significant uncertainty in both active surveillance and focal therapy. This consensus group paper provides a road-map for clinical p...
#1Hashim U. Ahmed(UCL: University College London)H-Index: 62
#2Richard Hindley(Hampshire Hospitals NHS Foundation Trust)H-Index: 21
Last. Mark Emberton(UCL: University College London)H-Index: 80
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Summary Background Radical whole-gland therapy can lead to significant genitourinary and rectal side-effects for men with localised prostate cancer. We report on whether selective focal ablation of unifocal and multifocal cancer lesions can reduce this treatment burden. Methods Men aged 45–80 years were eligible for this prospective development study if they had low-risk to high-risk localised prostate cancer (prostate specific antigen [PSA] ≤15 ng/mL, Gleason score ≤4 + 3, stage ≤T2), with no p...
The aim was to develop clinical guidelines for multi-parametric MRI of the prostate by a group of prostate MRI experts from the European Society of Urogenital Radiology (ESUR), based on literature evidence and consensus expert opinion. True evidence-based guidelines could not be formulated, but a compromise, reflected by “minimal” and “optimal” requirements has been made. The scope of these ESUR guidelines is to promulgate high quality MRI in acquisition and evaluation with the correct indicatio...
OBJECTIVE. The objective of our study was to investigate whether quantitative parameters derived from diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI (DCE-MRI) correlate with Gleason score and angiogenesis of prostate cancer. MATERIALS AND METHODS. Seventy-three patients who underwent preoperative MRI and radical prostatectomy were included in our study. A radiologist and pathologist located the dominant tumor on the MR images based on histopathologic correlation. For each dom...
Since quantitative apparent diffusion coefficients correlated significantly with tumor Gleason scores, diffusion-weighted MR imaging may serve as an important clinical tool by adding information about prostate cancer aggressiveness to the morphologic information provided by T2-weighted MR imaging.
Apparent diffusion coefficients determined with diffusion-weighted MR imaging at 3.0 T may be a potentially useful biomarker for prostate cancer aggressiveness.
Apparent diffusion coefficients obtained from 3-T diffusion-weighted MR images may be useful in the noninvasive assessment of the aggressiveness of prostate cancers that are visible on MR images and may aid in patient treatment.
Purpose: To investigate differences in apparent diffusion coefficient (ADC) and T2 values between dense and sparse regions in prostate cancer. Materials and Methods: Eighteen patients (median age, 61 years; range, 44–72 years) gave informed consent for this retrospective Research Ethics Board–approved study. Prior to radical prostatectomy, ADC (b value, 600 sec/mm2) and T2 maps were obtained by using 1.5-T magnetic resonance (MR) imaging. Twenty-eight peripheral zone (PZ) tumors were reviewed by...
#1Zhihua Li(UIC: University of Illinois at Chicago)
#2Guangyu Dan(UIC: University of Illinois at Chicago)
Last. Karen L. Xie(UIC: University of Illinois at Chicago)H-Index: 1
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Abstract null null Purpose null To evaluate the performance of parameters D, β, μ from the Fractional Order Calculus (FROC) model at differentiating peripheral zone (PZ) prostate cancer (PCa) null null null Material and Methods null 75 patients who underwent targeted MRI-guided TRUS prostate biopsy within 6 months of MRI were reviewed retrospectively. Regions of interest (ROI) were placed on suspicious lesions on MRI scans. ROIs were then correlated to pathological results based on core biopsy l...
Last. Xiaohua Wang(PKU: Peking University)H-Index: 2
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AIM null To investigate whether whole-lesion histogram analysis of apparent diffusion coefficient (ADC) values derived from mono-exponential and bi-exponential diffusion-weighted imaging (DWI) can differentiate lung cancer from benign pulmonary lesions. null null null MATERIALS AND METHODS null Thirty-two patients with lung cancer and 17 patients with benign pulmonary lesions were included retrospectively. All patients underwent DWI before surgery or biopsy. ADC histogram parameters, including m...
To investigate the value of volumetric ADC histogram metrics for evaluating lymphovascular space invasion (LVSI) status in stage I endometrioid adenocarcinoma (EAC). Preoperative MRI of 227 patients with stage I EAC were retrospectively analyzed. ADC histogram data were derived from the whole tumor with ROIs drawn on all slices of DWI scans (b = 0, 1000 s/mm2). The Student t-test was performed to compare ADC histogram metrics (minADC, maxADC, and meanADC; 10th, 25th, 50th, 75th, and 90th percent...
BACKGROUND Diffusion-weighted imaging (DWI) is an important method for clinically significant prostate cancer (csPCa) diagnosis; however, the Prostate Imaging-Reporting and Data System (PI-RADS) requires the subjective assessment of "markedly hypointense or not" on apparent diffusion coefficient (ADC) map. We hypothesize that weighted diffusion subtraction (WDS) images, created by weighted subtraction of high and low b-value DWIs, might better show areas of ADC values below a set threshold, thus...
: Prostate MRI is reported in clinical practice using the Prostate Imaging and Data Reporting System (PI-RADS). PI-RADS aims to standardize, as much as possible, the acquisition, interpretation, reporting, and ultimately the performance of prostate MRI. PI-RADS relies upon mainly subjective analysis of MR imaging findings, with very few incorporated quantitative features. The shortcomings of PI-RADS are mainly: low-to-moderate interobserver agreement and modest accuracy for detection of clinical...
Diffusion-weighted magnetic resonance imaging (DWI) can differentiate malignant from benign pulmonary nodules. However, it is difficult to differentiate pulmonary abscesses and mycobacterial infections (PAMIs) from lung cancers because PAMIs show restricted diffusion in DWI. The study purpose is to establish the role of ADC histogram for differentiating lung cancer from PAMI. There were 41 lung cancers (25 adenocarcinomas, 16 squamous cell carcinomas), and 19 PAMIs (9 pulmonary abscesses, 10 myc...
PURPOSE To assess the value of volumetric ADC histogram metrics in evaluating the histological subtype and grade of endometrial cancer. METHOD Preoperative MRI datasets of 317 patients with endometrial cancer were used to obtain volumetric ADC histogram metrics (tumour volume; minADC, maxADC and meanADC; 10th, 25th, 50th, 75th and 90th percentiles of ADC; skewness; and kurtosis). The Mann-Whitney test or Student's t-test was used to compare the difference in ADC histogram metrics between endomet...
Last. Hongqian Guo(NU: Nanjing University)H-Index: 21
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Purpose Prostate-specific membrane antigen (PSMA) positron emission tomography (PSMA-PET) is an ideal tool for staging and restaging of prostate cancer (PCa). This study was designed to investigate the prognostic role of preoperative 68Ga-PSMA-11 PET/CT in predicting pathological upgrading from multiparametric magnetic resonance imaging-targeted biopsy (mpMRI-TB) to final radical prostatectomy (RP) specimens in patients with localized PCa. Methods A total of 67 biopsy-confirmed localized PCa pat...
Abstract Purpose To explore the potential value of MRI texture analysis (TA) combined with prostate-related biomarkers to predict high-grade prostate cancer (HGPCa). Materials and methods Eighty-five patients who underwent MRI scanning, including T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) prior to trans-rectal ultrasound (TRUS)-guided core prostate biopsy, were retrospectively enrolled. TA parameters derived from T2WI and DWI, prostate-specific antigen (PSA), and free PSA (f...