The Distribution Kinetics of Topical 14C‐Sulfur Mustard in Rabbit Ocular Tissues and the Effect of Acetylcysteine

Published on Nov 18, 2003in Journal of Toxicology-cutaneous and Ocular Toxicology
· DOI :10.1081/CUS-120026300
Adina Amir16
Estimated H-index: 16
(Israel Institute for Biological Research),
Tamar Kadar26
Estimated H-index: 26
(Israel Institute for Biological Research)
+ 7 AuthorsM. Ross1
Estimated H-index: 1
Sources
Abstract
Sulfur mustard (2,2‐dichlorodiethyl sulfide; HD), is a potent alkylating agent which in liquid or vapor form is capable of causing severe injuries to skin and respiratory tract, and was shown to cause short‐ and long‐term ocular injuries. N‐Acetylcysteine (NAC) may act as a mucolytic agent, changing the “wetting” and scavenging properties of the cornea and thus the adhesion of HD. Moreover, NAC is a scavenger of HD, an antioxidant and a glutathione precursor, which was shown to reduce HD toxicity in various systems. The ocular distribution of 14C, after topical application of liquid 14C‐sulfur mustard (14C‐HD) to the rabbit cornea, and the role of NAC in reducing HD retention and toxicity are presented in this study. Groups of rabbits were exposed to 0.4 µL of liquid 14C‐HD, placed at the center of the cornea, with or without NAC treatment. Fifty µL NAC (10% aqueous solution) was topically applied, 10 minutes before and 10 minutes after HD exposure. Three time points were evaluated: 1, 6, and 24 hr after ...
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