Sputum Eosinophilia, Airway Hyperresponsiveness and Airway Narrowing in Young Adults with Former Asthma

Published on Jan 1, 2008in Allergology International4.806
· DOI :10.2332/ALLERGOLINT.O-06-461
Johsuke Hara12
Estimated H-index: 12
(Kanazawa University),
Masaki Fujimura53
Estimated H-index: 53
(Kanazawa University)
+ 20 AuthorsShinji Nakao59
Estimated H-index: 59
(Kanazawa University)
ABSTRACT Background 30–80% of outgrown asthma subjects develop symptoms again later in life. We investigated inflammation and function of lower airway in adolescents with former asthma. Methods 326 never-smoking young adults (mean age 24.0 years) were interviewed with special emphasis on history of asthma. Diagnosis of asthma was based on GINA guidelines. Former asthma subjects consisted of ones with a history of physician-diagnosed childhood asthma, who had been free of asthma symptoms without the use of medication for at least 10 years prior to the study. Provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 second (FEV 1 ) (PC 20 ) and eosinophil percentage in induced sputum were measured. Results 31 subjects were former asthma subjects (FBA), 11 subjects were current asthma subjects (CBA) and 284 subjects had no history of asthma (non-BA). PC 20 and FEV 1 /FVC ratio were significantly lower in the FBA group than in the non-BA group ( P P P 20 was significantly lower in the CBA group than in the FBA and non-BA groups ( P 1 , FEV 1 /FVC ratio and MMF were significantly lower in the CBA group than in the FBA group ( P P P P P P P Conclusions This study shows that subjects with long-term outgrown asthma continue to have airway eosinophilic inflammation, airway hyperresponsiveness and airway narrowing.
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