Time course of skeletal muscle repair and gene expression following acute hind limb ischemia in mice

DNA microarrays were used to measure the time course of gene expression during skeletal muscle damage and regeneration in mice following femoral artery ligation (FAL). We found 1,289 known sequences were differentially expressed between the FAL and control groups. Gene expression peaked on day 3, and the functional cluster “inflammation” contained the greatest number of genes. Muscle function was depressed for 3 days postligation, but returned...