Lyn Powell-Braxton
Medical University of South Carolina
Internal medicineEndocrinologyGenetically modified mouseReceptorLigationChemistryWild typeGrowth factorRatónCholesterolFamilial hypercholesterolemiaBone densityFemoral arterySkeletal muscleInsulin-like growth factorLDL receptorDiabetes mellitusApolipoprotein EApolipoprotein BMedicineBlood pressureBiology
Publications 18
#1Samar M. Hammad (MUSC: Medical University of South Carolina)H-Index: 24
#2Lyn Powell-Braxton (MUSC: Medical University of South Carolina)H-Index: 14
Last. Timothy J. Lyons (MUSC: Medical University of South Carolina)H-Index: 54
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Abstract Dyslipidemia accelerates vascular complications of diabetes. Nuclear magnetic resonance (NMR) analysis of lipoprotein subclasses is used to evaluate a mouse model of human familial hypercholesterolemia +/- streptozotocin (STZ)-induced diabetes. A double knockout (DKO) mouse (low-density lipoprotein receptor [LDLr] -/-; apolipoprotein B [apoB] mRNA editing catalytic polypeptide-1 [Apobec1] -/-) was studied. Wild-type (WT) and DKO mice received sham or STZ injections at age 7 weeks, yield...
16 CitationsSource
#1Samar M. Hammad (MUSC: Medical University of South Carolina)H-Index: 24
Last. Timothy J. LyonsH-Index: 54
view all 7 authors...
Background/Aims: The contribution of preexisting hypercholesterolemia to diabetic nephropathy remains unclear. We assessed the impact of hypercholesterolemia on diabetic nephropathy using a double knockout (DKO) mouse, null for the low-density lipoprotein receptor (Ldlr–/–) and the apoB mRNA editing catalytic polypeptide 1 (Apobec1–/–). Methods: Wild-type (WT) and DKO mice received sham or streptozotocin injections at age 7 weeks, yielding control (WT-C, DKO-C) and diabetic (WT-D, DKO-D) groups....
12 CitationsSource
#1Bolesław RutkowskiH-Index: 35
#2Tomas LenzH-Index: 9
Last. Jaroslav RacekH-Index: 24
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#1Bolesław RutkowskiH-Index: 35
#2Tomas LenzH-Index: 9
Last. Jaroslav RacekH-Index: 24
view all 48 authors...
1 CitationsSource
#1Nicholas F. PaoniH-Index: 16
#2Franklin PealeH-Index: 49
Last. Lyn Powell-BraxtonH-Index: 14
view all 11 authors...
DNA microarrays were used to measure the time course of gene expression during skeletal muscle damage and regeneration in mice following femoral artery ligation (FAL). We found 1,289 known sequences were differentially expressed between the FAL and control groups. Gene expression peaked on day 3 , and the functional cluster “inflammation” contained the greatest number of genes. Muscle function was depressed for 3 days postligation, but returned to normal by day 7 . Decreased muscle function was ...
141 CitationsSource
#1Ellen Filvaroff (Genentech)H-Index: 19
#2Susan Guillet (Genentech)H-Index: 3
Last. Dorothy French (Genentech)H-Index: 43
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Fish stanniocalcin (STC) inhibits uptake of calcium and stimulates phosphate reabsorption. To determine the role of the highly homologous mammalian protein, STC-1, we created and characterized transgenic mice that express STC-1 under control of a muscle-specific promoter. STC-1 transgenic mice were smaller than wild-type littermates and had normal growth plate cartilage morphology but increased cartilage matrix synthesis. In STC-1 mice, the rate of bone formation, but not bone mineralization, wa...
128 CitationsSource
#1Elizabeth Tomlinson (Genentech)H-Index: 4
#2Ling Fu (Genentech)H-Index: 18
Last. Timothy A. Stewart (Genentech)H-Index: 29
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The fibroblast growth factors (FGFs), and the corresponding receptors, are implicated in more than just the regulation of epithelial cell proliferation and differentiation. Specifically, FGF23 is a regulator of serum inorganic phosphate levels, and mice deficient in FGF receptor-4 have altered cholesterol metabolism. The recently described FGF19 is unusual in that it is nonmitogenic and appears to interact only with FGF receptor-4. Here, we report that FGF19 transgenic mice had a significant and...
518 CitationsSource
#1Daniel D. Bikle (UCSF: University of California, San Francisco)H-Index: 101
#2Sharmila Majumdar (UCSF: University of California, San Francisco)H-Index: 102
Last. Bernard P. Halloran (UCSF: University of California, San Francisco)H-Index: 69
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The importance of insulin-like growth factor I (IGF-I) for growth is well established. However, the lack of IGF-I on the skeleton has not been examined thoroughly. Therefore, we analyzed the structural properties of bone from mice rendered IGF-I deficient by homologous recombination (knockout [k/o]) using histomorphometry, peripheral quantitative computerized tomography (pQCT), and microcomputerized tomography (μCT). The k/o mice were 24% the size of their wild-type littermates at the time of st...
200 CitationsSource
#1Joan M. GreveH-Index: 21
#2Lisa J. BernsteinH-Index: 6
Last. Nicholas van BruggenH-Index: 24
view all 7 authors...
2 Citations
#1Renhui Yang (Genentech)H-Index: 1
#1Renhui Yang (Genentech)H-Index: 30
Last. Hongkui Jin (Genentech)H-Index: 23
view all 7 authors...
Abstract —Mice lacking ApoE ( Apoe –/–) develop initially hypercholesterolemia and latterly atherosclerosis. This study examined hemodynamics and endothelial function in 6-week-old Apoe –/– mice with hypercholesterolemia only, 7.5-months-old Apoe –/– mice with both hypercholesterolemia and atherosclerosis, and age matched controls. One day after implantation of catheters into the carotid artery, arterial pressure was measured in conscious, unrestrained mice. Compared with the respective controls...
79 CitationsSource