Microparticle-associated tissue factor activity and overt disseminated intravascular coagulation in patients with acute myelocytic leukemia

Microparticles (MPs) are considered as key components of the haemostatic system. These are small membrane vesicles shed from normal and/or tumour cells following activation or apoptosis. They can be captured in the developing thrombus and lead to thrombin generation by expression of procoagulant phospholipids (PL) and tissue factor (TF) [ 1 Furie B. Furie B.C. Mechanisms of thrombus formation. N Engl J Med. 2008; 359: 938-949 Crossref PubMed...