Transformation of polarized epithelial cells by apical mistrafficking of epiregulin
Volume: 110, Issue: 22, Pages: 8960 - 8965
Published: May 28, 2013
Abstract
Establishment and maintenance of apico-basolateral trafficking pathways are critical to epithelial homeostasis. Loss of polarity and trafficking fidelity are thought to occur as a consequence of transformation; however, here we report that selective mistrafficking of the epidermal growth factor receptor (EGFR) ligand epiregulin (EREG) from the basolateral to the apical cell surface drives transformation. Normally, EREG is preferentially...
Paper Details
Title
Transformation of polarized epithelial cells by apical mistrafficking of epiregulin
Published Date
May 28, 2013
Volume
110
Issue
22
Pages
8960 - 8965
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