Comparison of neutrophil infiltration between type 1 and type 2 autoimmune pancreatitis.

Published on May 1, 2015in Pancreatology3.629
· DOI :10.1016/J.PAN.2015.03.005
Toshiyuki Mitsuyama8
Estimated H-index: 8
(Kansai Medical University),
Kazushige Uchida30
Estimated H-index: 30
(Kansai Medical University)
+ 13 AuthorsKazuichi Okazaki85
Estimated H-index: 85
(Kansai Medical University)
Abstract Background Characteristics of type 2 autoimmune pancreatitis (AIP) is granulocyte epithelial lesions, called idiopathic duct-centric pancreatitis (IDCP). To clarify pathogenesis of IDCP, we investigated mechanism of neutrophil infiltration in type 1 AIP, called lymphoplasmacytic sclerosing pancreatitis (LPSP) and IDCP. Method This study was performed on resected pancreata from patients with alcoholic chronic pancreatitis (ACP, n = 10), LPSP (n = 10) and IDCP (n = 12). The number of neutrophils around the pancreatic ducts was counted. The expression of neutrophils chemoattractants granulocyte chemotactic protein-2 (GCP-2) and interleukin-8 (IL-8) in the pancreatic duct epithelia was examined using immunohistochemistry. The cell staining intensity is scored as negative (0), weak (1), moderate (2) or strong (3). Results The median number of neutrophils around the interlobular pancreatic ducts was significantly higher in IDCP (15.16; interquartile range [IQR]: 9.74–18.41) than in ACP (2.66; IQR: 1.33–4.33) (P  Conclusions Significantly increased neutrophil infiltration around the interlobular pancreatic duct in IDCP may depend on GCP-2.
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