Abstract Ionic-substituted hydroxyapatite (HAp) based materials may be a better choice than pure HAp owing to their similarity in chemical composition with biological apatite. The present study reports a process for the production of carbonated hydroxyapatite (CHAp) using microwaves. The CHAp was evaluated for its phase purity, chemical homogeneity, functionality, morphology, and solubility. The CHAp thus obtained was compared with a pure HAp and a biological apatite, which provides quite an interesting insight into the carbonate substitution. The in vitro ionic dissolution rates determined under physiological conditions clearly demonstrate the soluble nature of CHAp compared to HAp. The overall results indicate that the processed CHAp has increased resorption relative to pure HAp and has a chemical composition corresponding to some extent with that of biological apatite.
Biomaterials derived from natural sources have considerable interest in human health care. This study reports a simple method of designing a bone drug delivery system using porous bovine hydroxyapatite (BHA). The porous BHA blocks with different porosity were fabricated by a die-pressing method using polyvinylbutyral (PVB) as a porosifier. A model antibiot- ic drug, neomycin sulfate (NS) was loaded in the blocks and its in vitro release performance was studied. Fourier transform infrared (FTIR) ...
#1Nezahat Kivrak(METU: Middle East Technical University)H-Index: 1
#2A. Cuneyt Tas(METU: Middle East Technical University)H-Index: 27
Composite (biphasic) mixtures of two of the most important inorganic phases of synthetic bone applications-namely, calcium hydroxyapatite (Ca10(PO4)6(OH)2 (HA)) and tricalcium phosphate (Ca3(PO4)2 (TCP))-were prepared as submicrometer-sized, chemically homogeneous, and high-purity ceramic powders by using a novel, one-step chemical precipitation technique. Starting materials of calcium nitrate tetrahydrate and diammonium hydrogen phosphate salts that were dissolved in appropriate amounts in dist...
An attempt was made to enhance the bioresorbability of hydroxyapatite (HA) by controlling its particle size to nano/submicron level. A wet chemical method was employed for the synthesis of HA nanocrystals at low temperature in an aqueous medium having the ability of bioresorbtion in stimulated body fluid. The prepared free flowing nano HA was characterized for its phase purity, chemical homogeneity and functionality. The obtained results indicated that it has nanoscale morphological structure wi...
Hydroxyapatite (HA) is a calcium phosphate based bioceramic material rich in hard tissues such as bones and teeth. It is used as an artificial bone substitute in orthopaedic and dental applications. It can be derived from synthetic or natural resources. It has all the characteristic features of biomaterials, in particular, crystallographic similarity with natural bone minerals. However, crystallographic properties HA prepared from various resources are considerably different due to the material ...
Abstract Aim of this study concerns to the development of bioresorbable composite materials for bone repair and regeneration. Despite nano hydroxyapatite (HA) has wide range of medical applications, particles mobilization and slow resorbable nature limits its use in certain applications particularly, periodontal and alveolar ridge augmentation. To enhance its usage, we have prepared HA composite bone paste with a natural polysaccharide, chitosan, using wet chemical method at low temperature. The...
Surface modification and coupling of therapeutic molecules, tetracycline, onto coralline hydroxyapatite (CHA) and their in vitro evaluations were described in this study. Initially, CHA was graft polymerized with glycidylmethacrylate (GMA) using redox initiators and subsequently coupled to tetracycline through epoxy groups. The CHA grafted with polyGMA (CHA-g-PGMA) was characterized by Fourier transform infrared spectroscopy and powder X-ray diffraction (XRD) for proof of grafting. The absorptio...
Abstract Bi-phasic calcium phosphate (BCP) bioceramics containing hydroxyapatite (HA) and tri-calcium phosphate (TCP) phases have recently attracted attention as an ideal bone graft substitute due to their controlled resorption in the body fluid upon implantation. In this study, the HA and BCP phases were prepared by in situ method, using natural goniopora under microwave irradiation. Fourier-transform infrared (FT-IR) and powder X-ray diffraction (XRD) methods were employed to investigate proof...
#1R. Murugan(CLRI: Central Leather Research Institute)H-Index: 1
#2K. Panduranga Rao(CLRI: Central Leather Research Institute)H-Index: 15
Last. T.S. Sampath Kumar(IITs: Indian Institutes of Technology)H-Index: 33
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Xenogeneic bone procured from the slaughterhouse waste was deproteinated by heat treatment method intended for use as a bone substitute. The effect of heat treatment was investigated by thermal ana - lysis and by physico -chemical methods such as X -ray powder diffraction (XRD) and Fourier transformed infrared (FTIR) spectroscopy. The heat treatment temperatures for the bovine bone samples were pre - determined by thermogravime tric (TG) analysis. The XRD results revealed that the process of hea...
Abstract Manganese-doped mesoporous hydroxyapatite (MnHAp) nanorods, a bio-apatite were synthesized via pyridinium chloride mediated microwave approach using bio-waste Donax variabilis seashells to treat orthopedic infections. This is the first report on using pyridinium chloride mediated mesoporous MnHAp nanorods synthesis. Pure and Mn doped HAp samples were examined using Raman spectroscopy, X-ray powder diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) studies to confirm th...
Biomimetic synthesis of bioceramics using simulated body fluid (SBF) is a route to produce biomaterials with a more suitable microstructure and characteristics required for bone defect treatments. As matter of fact, the biomimetic method allows us to imitate the natural environment needed for the synthesis of bone-like materials, such as hydroxyapatite (HA). In this study, biomimetic HA was successfully synthesized through the microwave-assisted method by the employment of SBF in different ratio...
#1Shih-Ching Wu(CTUST: Central Taiwan University of Science and Technology)H-Index: 23
#2Hsueh-Chuan Hsu(CTUST: Central Taiwan University of Science and Technology)H-Index: 24
Last. Wen-Fu Ho(NUK: National University of Kaohsiung)H-Index: 9
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Hydroxyapatite (HA) has been vigorously studied for orthopedic and dental applications due to its excellent bioactivity, osteoconductivity, and osteoinductivity. This study aims to present a simple room-temperature aqueous precipitation method for obtaining carbonated HA nanoparticles of high purity from biowaste chicken eggshells. Biowaste chicken eggshells were used for preparing HA through aqueous precipitation method. Moreover, mulberry leaf extract was used as a template to regulate the mor...
Last. Qiaoyun Huang(HAU: Huazhong Agricultural University)H-Index: 43
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Abstract As one of the five most toxic heavy metals, cadmium pollution seriously endangers human health and food safety. Carbonate hydroxyapatite has attracted our attention because of its excellent cleaning ability. However, few ecofriendly synthetic processes of nanoscale carbonate hydroxyapatite limit its application. In this study, we designed a medium that was used to prepare carbonate hydroxyapatite through microbial mineralization. The nano-flaky structure gives it a large specific surfac...
Last. Diego H. S. Souza(UFRJ: Federal University of Rio de Janeiro)H-Index: 8
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Abstract To develop an orthopedic material for bone substitution, the substitute material must mimic living tissue from an anatomical and physiological point of view. The high wear and impact resistance besides the low friction coefficient, make ultra-high molecular weight polyethylene (UHMWPE) a suitable material to be used in orthopedic applications. However, UHMWPE is a bioinert material, not providing a proper interaction with the bone tissue surrounding to the implant. One way to mitigate t...
Hydroxyapatite (HAP, Ca10(PO4)6(OH)2) remains to be the foremost choice in biomedical field right from repair/replacement for the damaged hard tissues to be acting as effective drug delivery agent for tissue healing. Though, HAP is similar in composition with the mineral component of bone, some issues such as lack of mechanical and antimicrobial properties, low degradation, lesser drug loading capability, lower stimuli responsiveness, and targeted deficiency have continuously posed major challen...
Patients in dental hospitals often experience oral ulcerative lesions, which lead to pain and affect the patient’s quality of life. At present, the goal of treating oral ulcerative lesions with drugs is to reduce inflammation and promote ulcer healing. However, very few antibacterial and hemostatic drugs are designed to be suitable for the microenvironment of gingival ulcers. Based on this, we have designed a natural therapeutic agent for oral ulcerative lesions that meets the various requiremen...
Abstract In the present work, the effect of varying the carbonate to phosphate (CO32−/PO43−) molar ratios from 0.5 to 4 on the sintering behaviour of carbonated hydroxyapatite (CHA) synthesized by a wet chemical method were investigated. The sintering was performed under carbon dioxide atmosphere at 900 °C to maintain the B-type CHA structure. The derived powders as well as the sintered samples were characterized to determine the phase present, crystallographic parameters, the functional group r...