Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury
Abstract
Abnormal myelination is a major pathological sequela of chronic periventricular white matter injury in survivors of premature birth. We tested the hypothesis that myelination failure in chronic hypoxia-ischemia-induced periventricular white matter injury is related to persistent depletion of the oligodendrocyte (OL) precursor pool required to generate mature myelinating OLs.A neonatal rat model of hypoxia-ischemia was used where acute...
Paper Details
Title
Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury
Published Date
Apr 1, 2008
Journal
Volume
63
Issue
4
Pages
520 - 530
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