Original paper
Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force
Abstract
Cell migration through 3D tissue depends on a physicochemical balance between cell deformability and physical tissue constraints. Migration rates are further governed by the capacity to degrade ECM by proteolytic enzymes, particularly matrix metalloproteinases (MMPs), and integrin- and actomyosin-mediated mechanocoupling. Yet, how these parameters cooperate when space is confined remains unclear. Using MMP-degradable collagen lattices or...
Paper Details
Title
Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force
Published Date
Jun 24, 2013
Journal
Volume
201
Issue
7
Pages
1069 - 1084
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Notes
History